Shankar Hari, Kumar Neeta, Sandhir Rajat, Mittal Suneeta, Adhikari Tulsi, Kumar Arun, Rao D N
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
Panjab University, Chandigarh, 160014 India.
Indian J Clin Biochem. 2017 Oct;32(4):473-479. doi: 10.1007/s12291-017-0634-9. Epub 2017 Jan 17.
Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum.
A total of 200 primigravida {N = 100; NAP (Hb > 11 g/dl) and N = 100 AP (Hb = 8-11 g/dl) assigned daily (N = 50) and weekly (N = 50) supplementation} were recruited and overnight fasting blood samples were withdrawn at 13-16 weeks, after 3 months and 6 weeks postpartum. The serum iron, copper, zinc, magnesium and manganese were estimated by inductively coupled plasma-atomic emission spectrophotometer.
Serum manganese ( < 0.05) at baseline and magnesium ( < 0.01) at postpartum was significantly different between NAP and AP supplemented with daily IFA tablets. The trend of copper found to be increased during pregnancy and later declined at postpartum in both the groups. Daily supplementation resulted in significantly high iron ( < 0.05) in NAP during third trimester.
Hypozincemia and hypomagnesemia was observed in anaemic pregnancy supplemented with weekly and daily IFA respectively. Clear evidence of altered micronutrients levels during healthy and anaemic pregnancy was seen. The reference values may be drawn from this study for the nutritional assessment during pregnancy for healthy pregnancy outcomes.
Clinical Trial Registry-India, http://ctri.nic.in, CTRI/2014/10/005135.
怀孕是一种与身体的生理、心理和生化状态动态变化相关的现象，并且需要为发育中的胎儿增加营养摄入。作为抗氧化酶辅助因子或自身作为抗氧化剂的各种微量营养素水平会随着怀孕进程而改变。本纵向研究总结了在孕期和产后每日及每周口服铁叶酸（IFA）片的贫血初产妇（AP）和非贫血初产妇（NAP）中选定微量营养素水平的变化趋势。
总共招募了200名初产妇（N = 100；NAP（血红蛋白>11 g/dl）和N = 100名AP（血红蛋白= 8 - 11 g/dl），分为每日（N = 50）和每周（N = 50）补充组），在孕13 - 16周、产后3个月和产后6周采集过夜空腹血样。通过电感耦合等离子体原子发射分光光度计测定血清铁、铜、锌、镁和锰。
每日补充IFA片的NAP和AP组在基线时血清锰（<0.05）和产后镁（<0.01）存在显著差异。两组中铜的水平在孕期均升高，产后下降。每日补充导致NAP在孕晚期铁水平显著升高（<0.05）。
分别在每周和每日补充IFA的贫血孕妇中观察到低锌血症和低镁血症。在健康和贫血孕期均可见微量营养素水平改变的明确证据。本研究可为孕期营养评估以实现健康妊娠结局提供参考值。
印度临床试验注册中心，http://ctri.nic.in，CTRI/2014/10/005135 。
