Department of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznań, Poland.
PreMediCare New Med Medical Center, ul. Drużbickiego 13, 61-693 Poznan, Poland.
Int J Environ Res Public Health. 2021 Feb 2;18(3):1360. doi: 10.3390/ijerph18031360.
Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group ( = 23) (with iron and folate deficiency) and control group ( = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.
虽然同时补充铁和叶酸是合理的，但这些微量营养素与其他元素之间的潜在相互作用知之甚少。在这项研究中，我们旨在研究铁和叶酸补充对血清中微量营养素缺乏的年轻女性中选定必需和有毒元素水平的影响。共有 40 名女性参与了这项研究，并分为两组：研究组（=23）（缺铁和叶酸）和对照组（=17）。研究组接受铁和叶酸补充剂 3 个月。在基线和研究期结束时采集血样。女性完成了为期 3 天的食物摄入量记录。我们计算了所有参与者的体重指数（BMI）。在全血中分析细胞形态，在血清中测定生化参数。通过电感耦合等离子体质谱法（ICP-MS）测量血清中的元素。根据我们的结果，在研究组中，铁和叶酸的补充恢复了它们的水平；然而，它导致锌、钙和镁的水平显著下降。在对照组中，在研究结束时，铁的水平明显下降。有趣的是，两组的砷和钒水平都有所增加。总之，同时补充铁和叶酸会损害育龄妇女锌、钙和镁的水平。
