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尼日利亚因产CTX-M-15超广谱β-内酰胺酶感染导致的长期发热性疾病。

Prolonged febrile illness due to CTX-M-15 extended-spectrum β-lactamase-producing infection in Nigeria.

作者信息

Aboderin Oladipo A, Adefehinti Olufemi, Odetoyin Babatunde W, Olotu Amadin A, Okeke Iruka N, Adeodu Olugbenga O

机构信息

Department of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Nigeria.

Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

出版信息

Afr J Lab Med. 2012 Jun 4;1(1):16. doi: 10.4102/ajlm.v1i1.16. eCollection 2012.

DOI:10.4102/ajlm.v1i1.16
PMID:29062733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5644516/
Abstract

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.

摘要

我们报告了一名8岁败血症患者，其接受治疗五周后仍无反应。感染菌株产生的超广谱β-内酰胺酶（ESBL）未被检测到，被认为是治疗失败的原因。在第六周静脉注射亚胺培南后，发热持续消退。由于诊断限制以及随之而来的涉及长期支持治疗的治疗失败，资源有限的医院可能会因产ESBL感染而产生高昂的成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cf/5644516/f0397c74a7aa/AJLM-1-16-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cf/5644516/0378ec543268/AJLM-1-16-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cf/5644516/f0397c74a7aa/AJLM-1-16-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cf/5644516/0378ec543268/AJLM-1-16-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cf/5644516/f0397c74a7aa/AJLM-1-16-g002.jpg

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本文引用的文献

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J Med Microbiol. 2011 Jan;60(Pt 1):135-137. doi: 10.1099/jmm.0.021998-0. Epub 2010 Sep 2.
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Detection of bla(CTX-M-15) extended-spectrum beta-lactamase genes in Escherichia coli from hospital patients in Nigeria.尼日利亚医院患者大肠埃希菌中bla(CTX-M-15)超广谱β-内酰胺酶基因的检测
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Multiresistant Enterobacteriaceae: new threat of an old problem.
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J Clin Diagn Res. 2016 Feb;10(2):DC07-10. doi: 10.7860/JCDR/2016/16330.7254. Epub 2016 Feb 1.
多重耐药肠杆菌科细菌：一个老问题的新威胁。
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Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux.接合质粒pIP1206的序列，其通过16S rRNA甲基化介导对氨基糖苷类的抗性，并通过外排介导对亲水性氟喹诺酮类的抗性。
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