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没食子丙酯通过抑制 ROS 和 NF-B 通路对替莫唑胺治疗的恶性脑胶质瘤细胞发挥抗迁移作用。

Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-B Pathway.

机构信息

Department of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.

College of Medicine, Chang Gung University, Tao-Yuan 33302, Taiwan.

出版信息

J Immunol Res. 2017;2017:9489383. doi: 10.1155/2017/9489383. Epub 2017 Sep 14.

DOI:10.1155/2017/9489383
PMID:29062841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618759/
Abstract

In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-B pathway and possibly provide a novel prospective strategy for treating malignant glioma.

摘要

在这项研究中，我们证明了替莫唑胺（TMZ）和没食子丙酯（PG）联合使用可增强对人 U87MG 神经胶质瘤细胞迁移的抑制作用。PG 抑制了 TMZ 诱导的活性氧（ROS）生成。线粒体复合物 III 和 NADPH 氧化酶是两个关键的调节位点，可用于调节 TMZ 处理的 U87MG 细胞中的抗迁移作用。PG 可以通过抑制基质金属蛋白酶-2 和基质金属蛋白酶-9 的活性、ROS 的产生以及 NF-B 通路来增强 TMZ 的抗迁移作用，从而为治疗恶性神经胶质瘤提供新的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/195d6d89fad7/JIR2017-9489383.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/195d6d89fad7/JIR2017-9489383.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/8dce764ea0a0/JIR2017-9489383.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/fba705e49e18/JIR2017-9489383.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/aa195f9bf723/JIR2017-9489383.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/1b06025388ad/JIR2017-9489383.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/1323dcd8c41b/JIR2017-9489383.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/926021219560/JIR2017-9489383.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/fc223122212c/JIR2017-9489383.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8a/5618759/195d6d89fad7/JIR2017-9489383.008.jpg

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