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丙型肝炎患者肝细胞中巨型线粒体的形成——病例报告

Megamitochondria formation in hepatocytes of patient with chronic hepatitis C - a case report.

作者信息

Wieczorek Anna, Stępień Piotr M, Zarębska-Michaluk Dorota, Kryczka Wiesław, Pabjan Paweł, Król Teodora

机构信息

Department of Cell Biology and Electron Microscopy, Institute of Biology, Jan Kochanowski University, Kielce, Poland.

Clinic of Infectious Diseases, Regional Polyclinical Hospital, Kielce, Poland.

出版信息

Clin Exp Hepatol. 2017 Sep;3(3):169-175. doi: 10.5114/ceh.2017.68287. Epub 2017 Jun 12.

DOI:10.5114/ceh.2017.68287
PMID:29062908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5649480/
Abstract

Although chronic hepatitis C virus (HCV) infection affect 185 million people world-wide, pathomechanism of liver damage is still unclear. Electron microscopy can reveal liver injury in very early stage and help understanding the mechanisms that is crucial in the pathogenesis of chronic hepatitis C. We present the morphological changes in the liver of HCV infected 24-year-old female patient, using light and transmission electron microscopy. Examination by TEM revealed wide range of specific subcellular abnormalities in hepatocellular ultrastructure. The most common observed changes were ring-shaped nuclei with intranuclear inclusion, megamitochondria, and "membranous web" structures - the hallmark of RNA-viruses infection.

摘要

尽管慢性丙型肝炎病毒（HCV）感染在全球影响着1.85亿人，但肝损伤的发病机制仍不清楚。电子显微镜可以在非常早期阶段揭示肝损伤，并有助于理解在慢性丙型肝炎发病机制中至关重要的机制。我们使用光学显微镜和透射电子显微镜展示了一名24岁丙型肝炎病毒感染女性患者肝脏的形态学变化。透射电子显微镜检查揭示了肝细胞超微结构中广泛的特定亚细胞异常。最常见的观察到的变化是带有核内包涵体的环形核、巨型线粒体和“膜性网”结构——RNA病毒感染的标志。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/01ca05747787/CEH-3-30095-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/1120d9519405/CEH-3-30095-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/00d59077097f/CEH-3-30095-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/09375dd6c180/CEH-3-30095-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/1fb616969970/CEH-3-30095-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/01ca05747787/CEH-3-30095-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/1120d9519405/CEH-3-30095-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/00d59077097f/CEH-3-30095-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/09375dd6c180/CEH-3-30095-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/1fb616969970/CEH-3-30095-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e7/5649480/01ca05747787/CEH-3-30095-g005.jpg

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