合成聚羟基脂肪酸酯（PHA）的微生物的合成生物学。

Chen Guo-Qiang, Jiang Xiao-Ran, Guo Yingying

School of Life Sciences, Tsinghua University, Beijing 100084, China.

Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.

Synth Syst Biotechnol. 2016 Oct 7;1(4):236-242. doi: 10.1016/j.synbio.2016.09.006. eCollection 2016 Dec.

Microbial polyhydroxyalkanoates (PHA) have been produced as bioplastics for various purposes. Under the support of China National Basic Research 973 Project, we developed synthetic biology methods to diversify the PHA structures into homo-, random, block polymers with improved properties to better meet various application requirements. At the same time, various pathways were assembled to produce various PHA from glucose as a simple carbon source. At the end, bacteria were reconstructed to produce PHA in changing morphology for low cost production under unsterile and continuous conditions. The synthetic biology will advance the PHA into a bio- and material industry.

微生物聚羟基脂肪酸酯（PHA）已被生产用作各种用途的生物塑料。在中国国家基础研究973计划的支持下，我们开发了合成生物学方法，将PHA结构多样化为均聚物、无规聚合物、嵌段聚合物，其性能得到改善，以更好地满足各种应用需求。同时，组装了各种途径，以葡萄糖作为简单碳源生产各种PHA。最后，对细菌进行改造，使其在未灭菌和连续条件下以变化的形态生产PHA，从而实现低成本生产。合成生物学将推动PHA进入生物和材料产业。