Li Jing, Feng Juan, Wang Xian
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China.
Sheng Li Xue Bao. 2017 Oct 25;69(5):557-570.
Nitric oxide (NO), well known as the endothelium-derived relaxing factor (EDRF), has become increasingly recognized as an important determinant of cardiovascular diseases. A molecular pathway by which NO accomplishes various biochemical processes is the cGMP-independent post-translational modification of protein, S-nitrosylation. Here we review the biochemistry and regulating mechanisms of NO-related S-nitrosylation of proteins, and discuss the multiple roles of S-nitrosylation in vascular functions and pathology in particular.
一氧化氮（NO），作为内皮源性舒张因子（EDRF）广为人知，已越来越被视为心血管疾病的重要决定因素。NO实现各种生化过程的分子途径是蛋白质的非cGMP依赖性翻译后修饰——S-亚硝基化。在此，我们综述了与NO相关的蛋白质S-亚硝基化的生物化学及调节机制，尤其讨论了S-亚硝基化在血管功能和病理中的多重作用。
