Cong Bin-Hai, Zhu Xiao-Yan, Ni Xin
Department of Physiology, The Second Military Medical University, Shanghai 200433, China.
Sheng Li Xue Bao. 2017 Oct 25;69(5):571-578.
Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. The regeneration capacity of the adult mammalian heart is very limited, so that the lost cells are replaced by fibrotic scar. This is followed by remodeling of the surrounding myocardium, which includes cardiac hypertrophy and fibrosis, and makes the ventricular wall thicken and stiffen. This adverse cardiac remodeling leads to impaired cardiac function and eventually leads to heart failure. Extensive studies have revealed that microRNAs (miRNAs) play an essential role in cardiovascular diseases. microRNA-22 (miR-22) is one of the most abundant miRNA in the heart. Many studies have demonstrated that miR-22 plays critical roles in MI and subsequent cardiac remodeling. In this review, we summarized the recent research progresses, including the regulatory effects of miR-22 in oxidative stress, cardiac apoptosis, autophagy, hypertrophy, fibrosis and regeneration.
心肌梗死（MI）是全球发病和死亡的主要原因。成年哺乳动物心脏的再生能力非常有限，因此受损细胞由纤维化瘢痕替代。随后是周围心肌的重塑，包括心脏肥大和纤维化，导致心室壁增厚和僵硬。这种不良的心脏重塑会导致心脏功能受损，最终导致心力衰竭。广泛的研究表明，微小RNA（miRNA）在心血管疾病中起重要作用。微小RNA-22（miR-22）是心脏中最丰富的miRNA之一。许多研究表明，miR-22在心肌梗死及随后的心脏重塑中起关键作用。在本综述中，我们总结了最近的研究进展，包括miR-22在氧化应激、心脏细胞凋亡、自噬、肥大、纤维化和再生中的调节作用。
