Zhang Xiaonan, Dong Shaoyang, Jia Qiujin, Zhang Ao, Li Yanyang, Zhu Yaping, Lv Shichao, Zhang Junping
Department of Cardiovascular Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Department of Orthopaedics, Affiliated Hospital of Hebei College of Traditional Chinese Medicine, Hebei 050011, China.
Biosci Rep. 2019 Aug 2;39(8). doi: 10.1042/BSR20190788. Print 2019 Aug 30.
Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis, cardiac hypertrophy, and myocardial fibrosis, which is often caused by various cardiovascular diseases (CVDs) such as hypertension, acute myocardial infarction, heart failure (HF), etc. It is also an independent risk factor for a variety of CVDs, which will eventually to damage the heart function, promote cardiovascular events, and lead to an increase in mortality. MicroRNAs (miRNAs) can participate in a variety of CVDs through post-transcriptional regulation of target gene proteins. Among them, microRNA-30 (miR-30) is one of the most abundant miRNAs in the heart. In recent years, the study found that the miR-30 family can participate in VR through a variety of mechanisms, including autophagy, apoptosis, oxidative stress, and inflammation. VR is commonly found in ischemic heart disease (IHD), hypertensive heart disease (HHD), diabetic cardiomyopathy (DCM), antineoplastic drug cardiotoxicity (CTX), and other CVDs. Therefore, we will review the relevant mechanisms of the miR-30 in VR induced by various diseases.
心室重构（VR）是一个涉及心肌细胞凋亡、心脏肥大和心肌纤维化的复杂病理过程，常由高血压、急性心肌梗死、心力衰竭（HF）等各种心血管疾病（CVD）引起。它也是多种心血管疾病的独立危险因素，最终会损害心脏功能，促进心血管事件发生，并导致死亡率增加。微小RNA（miRNA）可通过对靶基因蛋白的转录后调控参与多种心血管疾病。其中，微小RNA-30（miR-30）是心脏中含量最丰富的miRNA之一。近年来，研究发现miR-30家族可通过多种机制参与心室重构，包括自噬、凋亡、氧化应激和炎症。心室重构常见于缺血性心脏病（IHD）、高血压性心脏病（HHD）、糖尿病性心肌病（DCM）、抗肿瘤药物心脏毒性（CTX）等心血管疾病。因此，我们将综述miR-30在各种疾病诱导的心室重构中的相关机制。
