Department of Radiology, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping District, Shenyang, 110004, Liaoning, People's Republic of China.
Division of MR Research, Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Park 336, Baltimore, MD, 21287, USA.
Mol Imaging Biol. 2018 Jun;20(3):473-481. doi: 10.1007/s11307-017-1136-0.
The purpose of this study is to evaluate the diagnostic concordance and metric correlations of amide proton transfer (APT) imaging with gadolinium-enhanced magnetic resonance imaging (MRI) and 2-deoxy-2-[F-]fluoro-D-glucose ([F]FDG) positron emission tomography (PET), using hybrid brain PET/MRI.
Twenty-one subjects underwent brain gadolinium-enhanced [F]FDG PET/MRI prospectively. Imaging accuracy was compared between unenhanced MRI, MRI with enhancement, APT-weighted (APTW) images, and PET based on six diagnostic criteria. Among tumors, the McNemar test was further used for concordance assessment between gadolinium-enhanced imaging, APT imaging, and [F]FDG PET. As well, the relation of metrics between APT imaging and PET was analyzed by the Pearson correlation analysis.
APT imaging and gadolinium-enhanced MRI showed superior and similar diagnostic accuracy. APTW signal intensity and gadolinium enhancement were concordant in 19 tumors (100 %), while high [F]FDG avidity was shown in only 12 (63.2 %). For the metrics from APT imaging and PET, there was significant correlation for 13 hypermetabolic tumors (P < 0.05) and no correlation for the remaining six [F]FDG-avid tumors.
APT imaging can be used to increase diagnostic accuracy with no need to administer gadolinium chelates. APT imaging may provide an added value to [F]FDG PET in the evaluation of tumor metabolic activity during brain PET/MR studies.
本研究旨在评估酰胺质子转移（APT）成像与钆增强磁共振成像（MRI）和 2-脱氧-2-[F]-氟-D-葡萄糖（[F]FDG）正电子发射断层扫描（PET）的诊断一致性和度量相关性，使用混合脑 PET/MRI。
21 名受试者前瞻性接受脑钆增强[F]FDG PET/MRI 检查。使用六种诊断标准，比较未增强 MRI、增强 MRI、APT 加权（APTW）图像和 PET 的成像准确性。在肿瘤中，进一步使用 McNemar 检验评估增强成像、APT 成像和[F]FDG PET 的一致性。同时，通过 Pearson 相关分析分析 APT 成像和 PET 之间的度量关系。
APT 成像和钆增强 MRI 具有优越和相似的诊断准确性。在 19 个肿瘤中（100%），APTW 信号强度与钆增强一致，而只有 12 个（63.2%）显示高[F]FDG 摄取。对于 APT 成像和 PET 的指标，13 个高代谢肿瘤（P<0.05）有显著相关性，而其余 6 个[F]FDG 摄取肿瘤无相关性。
APT 成像可用于提高诊断准确性，而无需使用钆螯合物。在脑 PET/MR 研究中，APT 成像可能为[F]FDG PET 评估肿瘤代谢活性提供附加价值。
