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拓宽生物样本研究的障碍。

Obstacles to Widening Biosample Research.

机构信息

Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320b, 4052, Basel, Switzerland.

Hematology Clinic, University Hospital of Basel, Basel, Switzerland.

出版信息

Sci Eng Ethics. 2019 Feb;25(1):113-128. doi: 10.1007/s11948-017-9985-0. Epub 2017 Oct 23.

Abstract

Switzerland has an excellent culture of medical research and is a melting pot for medical experts with international expertise. Nevertheless, as in other countries, the resources available to medical researchers are not being fully used. Biological samples, which enable a host of medical research studies to be carried out without invasive methods involving patients, are frequently left unused or forgotten. The aim of this study is to examine the experiences of biobank stakeholders regarding the use or underuse of biosamples, in order to develop paths to optimize biosample research. Interviews were carried out with 36 biobank stakeholders in Switzerland concerning their experiences with biosample use, and the possible obstacles at each stage of the process. Interviews revealed that standard operating procedures were the most frequently cited obstacle, although these were not judged to be severe hindrances. Despite a stated desire to develop biosample research, skepticism of sharing networks and wariness of new partnerships were strong themes. Biobanking still functions as an emerging field, in which exchange practices have yet to be established at the national and international levels. Sample exchange continues to function largely based on personal contacts; while this is an inherent feature of competitive medical research, opportunities for large-scale studies may be lost due to excessive caution.

摘要

瑞士拥有卓越的医学研究文化,是汇聚国际医学专业知识的专家的熔炉。然而,与其他国家一样,医学研究人员可利用的资源并未得到充分利用。生物样本使许多无需对患者进行侵入性方法的医学研究成为可能,但这些样本经常被闲置或遗忘。本研究旨在探讨生物银行利益相关者在使用或未充分使用生物样本方面的经验,以制定优化生物样本研究的途径。在瑞士,我们对 36 名生物银行利益相关者进行了访谈,了解他们在生物样本使用方面的经验,以及在该过程的各个阶段可能遇到的障碍。访谈显示,标准操作程序是被引用最多的障碍,尽管这些程序并不被认为是严重的阻碍。尽管有发展生物样本研究的愿望,但对共享网络的怀疑和对新伙伴关系的谨慎态度仍然是强烈的主题。生物库仍然是一个新兴领域,在国家和国际层面尚未建立样本交换的实践。样本交换仍然主要基于个人联系;虽然这是竞争激烈的医学研究的固有特征,但由于过度谨慎,可能会错失大规模研究的机会。

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