不育症患者 15 号环状染色体精子的正常现象：病例报告。
The normality of sperm in an infertile man with ring chromosome 15: a case report.
机构信息
Department of Infertility, Green Bell Clinic, Kitamachi 2-160, Toyota, Aichi, 471-0027, Japan.
Department of Infertility, Royal Bell Clinic, Midori-ku, Nagoya, Aichi, 458-0801, Japan.
出版信息
J Assist Reprod Genet. 2018 Feb;35(2):251-256. doi: 10.1007/s10815-017-1061-9. Epub 2017 Oct 23.
PURPOSE
The purpose of this report is to analyze the chromosome status and fertilization capability of sperm obtained from an infertile male patient with ring chromosome 15.
METHODS
This was a case report at a private in vitro fertilization clinic. A man diagnosed with severe oligozoospermia carrying ring chromosome 15. To evaluate the chromosome status and fertilization capability, sperm from a patient carrying ring chromosome 15 were injected into enucleated mouse oocytes.
RESULTS
The karyotypes of motile sperm from a patient carrying ring chromosome 15 were normal, and ring chromosome 15 was not observed in the chromosome spread samples of 1PN. In addition, these motile sperm retained the fertilization capability. However, the fertilization rates decreased (85.2, 76.2, and 64.3%, respectively) along with the decline of the aspect ratio of the sperm head (≥ 1.50, 1.30-1.49, and < 1.30, respectively).
CONCLUSIONS
The karyotypes were normal without ring chromosome 15, and motile sperm with a high aspect ratio showed adequate potential for fertilization.
目的
本报告旨在分析一名患有 15 号环状染色体的不育男性患者精子的染色体状态和受精能力。
方法
这是一家私人体外受精诊所的病例报告。一名患有严重少精症并携带 15 号环状染色体的男性。为了评估染色体状态和受精能力，将携带 15 号环状染色体的患者的精子注入去核的小鼠卵母细胞中。
结果
携带 15 号环状染色体的活动精子的核型正常，在 1PN 的染色体展开样本中未观察到环状染色体 15。此外，这些活动精子保留了受精能力。然而，受精率随着精子头部的长宽比（≥1.50、1.30-1.49 和 <1.30）的降低而降低（分别为 85.2%、76.2%和 64.3%）。
结论
染色体核型正常，无 15 号环状染色体，具有高长宽比的活动精子显示出充足的受精潜力。
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