Herold Christina, Paulitschek Christina, Palomero-Gallagher Nicola, Güntürkün Onur, Zilles Karl
C. and O. Vogt Institute of Brain Research, Medical Faculty, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany.
Institute of Neuroscience and Medicine INM-1, Research Center Jülich, Jülich, Germany.
J Comp Neurol. 2018 Feb 15;526(3):439-466. doi: 10.1002/cne.24344. Epub 2017 Nov 10.
At the beginning of the 20th century it was suggested that a complex group of nuclei in the avian posterior ventral telencephalon is comparable to the mammalian amygdala. Subsequent findings, however, revealed that most of these structures share premotor characteristics, while some indeed constitute the avian amygdala. These developments resulted in 2004 in a change of nomenclature of these nuclei, which from then on were named arcopallial or amygdala nuclei and referred to as the arcopallium/amygdala complex. The structural basis for the similarities between avian and mammalian arcopallial and amygdala subregions is poorly understood. Therefore, we analyzed binding site densities for glutamatergic AMPA, NMDA and kainate, GABAergic GABA , muscarinic M , M and nicotinic acetylcholine (nACh; α β subtype), noradrenergic α and α , serotonergic 5-HT and dopaminergic D receptors using quantitative in vitro receptor autoradiography combined with a detailed analysis of the cyto- and myelo-architecture. Our approach supports a segregation of the pigeon's arcopallium/amygdala complex into the following subregions: the arcopallium anterius (AA), the arcopallium ventrale (AV), the arcopallium dorsale (AD), the arcopallium intermedium (AI), the arcopallium mediale (AM), the arcopallium posterius (AP), the nucleus posterioris amygdalopallii pars basalis (PoAb) and pars compacta (PoAc), the nucleus taeniae amgygdalae (TnA) and the area subpallialis amygdalae (SpA). Some of these subregions showed further subnuclei and each region of the arcopallium/amygdala complex are characterized by a distinct multi-receptor density expression. Here we provide a new detailed map of the pigeon's arcopallium/amygdala complex and compare the receptor architecture of the subregions to their possible mammalian counterparts.
20世纪初有人提出，鸟类腹侧端脑后部的一组复杂核团与哺乳动物的杏仁核相当。然而，随后的研究发现，这些结构中的大多数具有运动前区特征，而有些结构确实构成了鸟类的杏仁核。这些进展在2004年导致了这些核团命名的改变，从那时起它们被称为弓状皮质或杏仁核核团，并被称为弓状皮质/杏仁核复合体。鸟类和哺乳动物弓状皮质及杏仁核亚区之间相似性的结构基础仍知之甚少。因此，我们使用定量体外受体放射自显影技术，并结合细胞和髓鞘结构的详细分析，分析了谷氨酸能AMPA、NMDA和海人藻酸、GABA能GABA、毒蕈碱M、M和烟碱型乙酰胆碱（nACh；αβ亚型）、去甲肾上腺素能α和α、5-羟色胺能5-HT以及多巴胺能D受体的结合位点密度。我们的方法支持将鸽子的弓状皮质/杏仁核复合体分为以下亚区：前弓状皮质（AA）、腹侧弓状皮质（AV）、背侧弓状皮质（AD）、中间弓状皮质（AI）、内侧弓状皮质（AM）、后弓状皮质（AP）、杏仁体苍白球后部基底部分（PoAb）和致密部分（PoAc）、杏仁核带核（TnA）以及杏仁核皮质下区（SpA）。其中一些亚区显示出进一步的亚核，并且弓状皮质/杏仁核复合体的每个区域都具有独特的多受体密度表达特征。在这里，我们提供了一份鸽子弓状皮质/杏仁核复合体的新详细图谱，并将这些亚区的受体结构与其可能的哺乳动物对应物进行了比较。
