Jensen Jeffrey T, Hanna Carol, Mishler Emily, Lim Jeong Y, Slayden Ov D
Department of Obstetrics & Gynecology, Oregon Health & Science University (OHSU), Portland, OR, USA.
Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR, USA.
J Med Primatol. 2018 Feb;47(1):40-45. doi: 10.1111/jmp.12317. Epub 2017 Oct 24.
We evaluated whether menstrual cycle phase influences the assessment of tubal patency by hysterosalpingography (HSG) in baboons.
Retrospective analysis of baseline tubal patency studies and serum estradiol (E ) and progesterone (P4) values obtained from female baboons used as models for development of non-surgical permanent contraception in women. The main outcome measure was bilateral tubal patency (BTP) in relationship with estradiol level.
Female baboons (n = 110) underwent a single (n = 81), two (n = 26), or three (n = 3) HSG examinations. In 33/142 (23%) HSG examinations, one or both tubes showed functional occlusion (FO). The median E in studies with BTP (49 pg/mL) was significantly higher than in those studies with FO (32 pg/mL, P = .005). Among 18 animals with repeat examinations where serum E changed from <60 to ≥ 60 pg/mL, 13 results changed from FO to BTP (P = .0001). No sets showed a change from BTP to FO with an increase in estradiol.
In baboons, functional occlusion of the fallopian tube is associated with low estradiol levels, supporting a role for estrogen-mediated relaxation of the utero-tubal junction.
我们评估了月经周期阶段是否会影响狒狒子宫输卵管造影术（HSG）对输卵管通畅性的评估。
对用作女性非手术永久性避孕方法开发模型的雌性狒狒的基线输卵管通畅性研究以及血清雌二醇（E）和孕酮（P4）值进行回顾性分析。主要结局指标是与雌二醇水平相关的双侧输卵管通畅性（BTP）。
雌性狒狒（n = 110）接受了一次（n = 81）、两次（n = 26）或三次（n = 3）HSG检查。在142次HSG检查中的33次（23%）中，一根或两根输卵管显示功能性阻塞（FO）。BTP研究中的E中位数（49 pg/mL）显著高于FO研究中的E中位数（32 pg/mL，P = .005）。在18只进行重复检查且血清E从<60 pg/mL变为≥60 pg/mL的动物中，13次结果从FO变为BTP（P = .0001）。没有一组显示随着雌二醇增加从BTP变为FO。
在狒狒中，输卵管功能性阻塞与低雌二醇水平相关，支持雌激素介导的子宫输卵管连接部松弛的作用。
