Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.
Department of Ultrasound, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.
Eur J Radiol. 2020 Apr;125:108891. doi: 10.1016/j.ejrad.2020.108891. Epub 2020 Feb 20.
To compare hysterosalpingo-contrast-sonography (HyCoSy) and magnetic resonance-hysterosalpingography (MR-HSG) in the diagnosis of fallopian tubal patency.
The databases of PubMed, Embase, and the Cochrane Library were searched for records up to November 30, 2019. Studies involved in the diagnostic detection of HyCoSy or MR-HSG for fallopian tubal patency using conventional HSG or laparoscopy as the reference test were included. Data was analyzed by meta-analysis. We compared sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (sROC) plots of both HyCoSy and MR-HSG. Quality was assessed using the QUADAS-2 tool.
The analysis included 24 articles involving 1340 patients. HyCoSy was studied in 17 studies, and MR-HSG was studied in seven studies. For HyCoSy in diagnosis of fallopian tubal patency, pooled sensitivity was 89 % (95 % confidence interval [CI], 87 %-91 %), and specificity was 93 % (95 % CI, 91 %-94 %). For MR-HSG in diagnosis of fallopian tubal patency, pooled sensitivity was 100 % (95 % CI, 98 %-100 %), and specificity was 82 % (95 % CI, 74 %-89 %). The sROC showed similar diagnostic accuracy for MR-HSG and HyCoSy. 3D/4D HyCoSy with ultrasound microbubbles had equal sensitivity (95 % vs. 100 %, P = 0.186) and significantly higher specificity (94 % vs. 82 %, P = 0.005) compared with MR-HSG.
HyCoSy and MR-HSG showed similar overall diagnostic performance for diagnosing fallopian tubal patency. 3D/4D HyCoSy with ultrasound microbubbles could significantly improve the diagnostic specificity of HyCoSy.
比较子宫输卵管造影超声检查（HyCoSy）和磁共振子宫输卵管造影（MR-HSG）在输卵管通畅性诊断中的应用。
检索PubMed、Embase 和 Cochrane 图书馆的数据库，检索截至 2019 年 11 月 30 日的记录。纳入研究采用传统子宫输卵管造影或腹腔镜作为参考标准，评估 HyCoSy 或 MR-HSG 对输卵管通畅性的诊断检测。采用 Meta 分析进行数据分析。我们比较了 HyCoSy 和 MR-HSG 的敏感性、特异性、阳性和阴性似然比（PLR 和 NLR）、诊断优势比（DOR）和汇总受试者工作特征（sROC）曲线。采用 QUADAS-2 工具评估质量。
该分析纳入了 24 项研究，涉及 1340 例患者。HyCoSy 研究 17 项，MR-HSG 研究 7 项。HyCoSy 诊断输卵管通畅性的 pooled 敏感性为 89 %（95 %置信区间 [CI]，87 %-91 %），特异性为 93 %（95 % CI，91 %-94 %）。MR-HSG 诊断输卵管通畅性的 pooled 敏感性为 100 %（95 % CI，98 %-100 %），特异性为 82 %（95 % CI，74 %-89 %）。sROC 显示 MR-HSG 和 HyCoSy 的诊断准确性相似。与 MR-HSG 相比，超声微泡 3D/4D HyCoSy 的敏感性（95 % 比 100 %，P = 0.186）相当，特异性（94 % 比 82 %，P = 0.005）显著提高。
HyCoSy 和 MR-HSG 对诊断输卵管通畅性的总体诊断性能相似。超声微泡 3D/4D HyCoSy 可显著提高 HyCoSy 的诊断特异性。
