氨基酸神经递质的脑脊液梯度
CSF gradients for amino acid neurotransmitters.
作者信息
Crawford P M, Lloyd K G, Chadwick D W
机构信息
Mersey Regional Medical and Surgical Neurology Unit, Walton Hospital, Liverpool, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1193-200. doi: 10.1136/jnnp.51.9.1193.
Amino acid concentrations were measured in CSF samples obtained by lumbar puncture in 51 patients, cervical puncture in 16 patients, spinal drains in nine patients, ventricular taps in five patients and from below a spinal block in six patients. There was evidence of a rostrocaudal gradient for GABA and taurine and a reverse gradient for alanine and asparagine. Lumbar CSF glycine concentrations rose with increasing age whilst GABA concentrations fell. Women had significantly lower concentrations of asparagine and glutamine and elevated taurine compared to men. The influence of biological factors and gradients must be taken into account before the interpretation of changes in CSF amino acid concentrations.
对51例通过腰椎穿刺获取的脑脊液样本、16例通过颈椎穿刺获取的样本、9例通过脊髓引流获取的样本、5例通过脑室穿刺获取的样本以及6例通过脊髓阻滞下方获取的样本中的氨基酸浓度进行了测量。有证据表明，γ-氨基丁酸（GABA）和牛磺酸存在头尾梯度，而丙氨酸和天冬酰胺则呈相反梯度。腰椎脑脊液中的甘氨酸浓度随年龄增长而升高，而GABA浓度则下降。与男性相比，女性的天冬酰胺和谷氨酰胺浓度显著较低，牛磺酸浓度升高。在解释脑脊液氨基酸浓度变化之前，必须考虑生物学因素和梯度的影响。
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