在气脑造影术中抽取的脑脊液在人体单胺代谢研究中的应用。
Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man.
作者信息
Garelis E, Sourkes T L
出版信息
J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):704-10. doi: 10.1136/jnnp.37.6.704.
Abstract
Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested.
摘要
气脑造影术（PEG）期间注入空气后获得的脑脊液（CSF）中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度显著高于注射前抽取的腰段脑脊液。两种酸各自的“混合”脑脊液样本和腰段脑脊液样本中的水平之间存在高度相关性。腰段HVA的浓度与脑脊液压力呈负相关，但5-HIAA的浓度与脑脊液压力无此相关性。与对照组相比，一组癫痫患者的两个脑脊液样本中5-HIAA水平均较低。在两名Kufs病患者和一名尼曼-皮克病患者中，腰段样本中HVA的浓度非常低。建议在人体单胺代谢研究中应用标准化的PEG技术。
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本文引用的文献
1
On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method.关于高香草酸在脑和脑脊液中的存在及其荧光法测定
Life Sci (1962). 1963 Jul(7):448-58. doi: 10.1016/0024-3205(63)90132-2.
2
5-Hydroxyindoles in human cerebrospinal fluids.人脑脊液中的5-羟基吲哚
Nature. 1960 Jun 25;186:1050-1. doi: 10.1038/1861050a0.
3
Metabolic fate of l-[14C] DOPA in cerebrospinal fluid and blood plasma of humans.l-[14C]多巴在人体脑脊液和血浆中的代谢命运。
Brain Res. 1967 Feb;4(1):106-9. doi: 10.1016/0006-8993(67)90154-0.
4
Cerebrospinal fluid 5-hydroxyindoleactiic acid and homovanillic acid in psychiatric patients.精神疾病患者脑脊液中的5-羟吲哚乙酸和高香草酸
Int J Neuropharmacol. 1969 May;8(3):255-62. doi: 10.1016/0028-3908(69)90046-x.
5
Acid metabolites from monoamines in cerebrospinal fluid of chronic schizophrenics.慢性精神分裂症患者脑脊液中单胺类物质的酸性代谢产物
Br J Psychiatry. 1969 Jan;115(518):95-8. doi: 10.1192/bjp.115.518.95.
6
The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetized dog.未麻醉犬脑室循环灌注系统中5-羟吲哚-3-乙酸和3-甲氧基-4-羟基苯乙酸的主动转运
J Physiol. 1968 Dec;199(2):397-425. doi: 10.1113/jphysiol.1968.sp008660.
7
[On the diagnostic value of homovanillic acid in the cerebrospinal fluid].[论脑脊液中高香草酸的诊断价值]
Wien Klin Wochenschr. 1967 Nov 3;79(44):815-8.
8
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9
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Eur J Pharmacol. 1967 Sep;1(5):363-8. doi: 10.1016/0014-2999(67)90096-9.
10
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J Psychosom Res. 1971 Sep;15(3):375-8. doi: 10.1016/0022-3999(71)90051-1.
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