Garelis E, Sourkes T L
J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):704-10. doi: 10.1136/jnnp.37.6.704.
Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested.
气脑造影术（PEG）期间注入空气后获得的脑脊液（CSF）中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度显著高于注射前抽取的腰段脑脊液。两种酸各自的“混合”脑脊液样本和腰段脑脊液样本中的水平之间存在高度相关性。腰段HVA的浓度与脑脊液压力呈负相关，但5-HIAA的浓度与脑脊液压力无此相关性。与对照组相比，一组癫痫患者的两个脑脊液样本中5-HIAA水平均较低。在两名Kufs病患者和一名尼曼-皮克病患者中，腰段样本中HVA的浓度非常低。建议在人体单胺代谢研究中应用标准化的PEG技术。
