Curzio J L, Reid J L, Kennedy S, Elliott H L, Rubin P C
University Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
J Hum Hypertens. 1987 Sep;1(2):131-6.
A group of 175 patients have attended for four years a microcomputer based, nurse practitioner managed clinic for the long term care of hypertension. Improvement in blood pressure (BP) control was seen initially and has been maintained. Drug treatment has been with a beta blocker followed if necessary by a diuretic and/or a vasodilator. Despite individual dietary and 'stop smoking' advice, there was no marked change in body weight while only males reduced smoking. A significant increase in non fasting serum cholesterol (6.4 +/- 1.3 to 6.6 +/- 1.3 mmol/l) and glucose (5.5 +/- to 6.1 +/- 2.5 mmol/l) was seen overall, but was restricted to those patients taking a thiazide diuretic (with or without other drugs). These findings indicate the need for a more systematic collection of information on effects of long term treatment and for the development of better strategies for improving lifestyle.
一组175名患者四年来一直在一家由护士执业者管理、基于微型计算机的诊所接受高血压长期护理。最初观察到血压（BP）控制有所改善，且一直保持。药物治疗采用β受体阻滞剂，必要时加用利尿剂和/或血管扩张剂。尽管给出了个性化的饮食和“戒烟”建议，但体重没有明显变化，只有男性吸烟量减少。总体上非空腹血清胆固醇显著升高（从6.4±1.3毫摩尔/升升至6.6±1.3毫摩尔/升），血糖也显著升高（从5.5±升至6.1±2.5毫摩尔/升），但仅限于服用噻嗪类利尿剂（无论是否加用其他药物）的患者。这些发现表明需要更系统地收集长期治疗效果的信息，并制定更好的改善生活方式的策略。
