Ikram M Arfan, Brusselle Guy G O, Murad Sarwa Darwish, van Duijn Cornelia M, Franco Oscar H, Goedegebure André, Klaver Caroline C W, Nijsten Tamar E C, Peeters Robin P, Stricker Bruno H, Tiemeier Henning, Uitterlinden André G, Vernooij Meike W, Hofman Albert
Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Eur J Epidemiol. 2017 Sep;32(9):807-850. doi: 10.1007/s10654-017-0321-4. Epub 2017 Oct 24.
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.
鹿特丹研究是一项前瞻性队列研究，自1990年起在荷兰鹿特丹市开展。该研究的目标疾病包括心血管疾病、内分泌疾病、肝脏疾病、神经系统疾病、眼科疾病、精神疾病、皮肤病、耳鼻喉科疾病、运动系统疾病和呼吸系统疾病。截至2008年，鹿特丹研究队列由14926名年龄在45岁及以上的受试者组成。自2016年起，该队列扩大到40岁及以上的人群。鹿特丹研究的结果已发表在1500多篇研究文章和报告中（见www.erasmus - epidemiology.nl/rotterdamstudy ）。本文阐述了该研究的基本原理及其设计。同时还总结了主要研究结果，并更新了研究目标和方法。
