Nemes Attila, Földeák Dóra, Domsik Péter, Kalapos Anita, Kormányos Árpád, Borbényi Zita, Forster Tamás
2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Division of Haematology, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
J Clin Ultrasound. 2018 Mar;46(3):183-187. doi: 10.1002/jcu.22547. Epub 2017 Oct 24.
Cardiac amyloidosis (CA) is as an infiltrative disorder primarily caused by extracellular tissue deposition of amyloid fibrils in the myocardial interstitium. The current study was designed to test whether alterations in ascending aortic elastic properties could be detected by echocardiography in CA patients, and to compare their results to controls.
We included 19 CA patients from which CA proved to be AL amyloidosis in 17 cases and transthyretin (TTR) amyloidosis in 2 cases. Their results were compared to 20 age-, gender-, and risk factor-matched controls.
There was significantly greater interventricular septum and left ventricular (LV) posterior wall thickness, lower LV ejection fraction and greater E/A in CA patients than in controls, suggesting systolic, and diastolic dysfunction. CA patients also showed significantly reduced aortic strain and pulsatile change in aortic diameter, and increased aortic stiffness index.
These results suggest increased aortic stiffness in CA patients.
心脏淀粉样变性（CA）是一种浸润性疾病，主要由淀粉样原纤维在心肌间质中的细胞外组织沉积引起。本研究旨在通过超声心动图检测CA患者升主动脉弹性特性的改变，并将其结果与对照组进行比较。
我们纳入了19例CA患者，其中17例经证实为AL型淀粉样变性，2例为转甲状腺素蛋白（TTR）型淀粉样变性。将他们的结果与20例年龄、性别和危险因素相匹配的对照组进行比较。
与对照组相比，CA患者的室间隔和左心室（LV）后壁厚度明显更大，LV射血分数更低，E/A更大，提示收缩和舒张功能障碍。CA患者还表现出主动脉应变和主动脉直径搏动变化明显降低，主动脉僵硬度指数增加。
这些结果表明CA患者的主动脉僵硬度增加。
