Cho Nicholas S, Jenabi Mehrnaz, Arevalo-Perez Julio, Brennan Nicole, Young Robert J, Karimi Sasan, Holodny Andrei I, Peck Kyung K
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY.
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY.
J Neuroimaging. 2018 Mar;28(2):199-205. doi: 10.1111/jon.12478. Epub 2017 Oct 24.
The corpus callosum (CC) has an important role in regulating interhemispheric transfer and is thought to be instrumental in contralateral brain reorganization in patients with brain tumors, as suggested by a previous study reporting callosal differences between language dominance groups through diffusion tensor imaging (DTI) characteristics. The purpose of this study was to explore the structural differences in the CC between high-grade gliomas (HGGs) and metastatic tumors (METs) using the DTI characteristics of fractional anisotropy (FA), mean diffusivity (MD), and axial diffusivity (AD).
HGG (n = 30) and MET (n = 20) subjects with Magnetic Resonance Imaging (MRI) scans including DTI were retrospectively studied. The tumor and CC were segmented using the 3-dimensional T1-weighted scans to determine their volumes. The region of interest (ROI; mean volume of the ROI = 3,090 ± 464 mm ) of the body of the CC was overlaid onto the DTI parametric maps to obtain the averaged FA, MD, and AD values.
There were significant differences in the distributions of FA and MD values between the two patient groups (mean FA for HGG/MET = .691/.646, P < .05; mean MD for HGG/MET = .894×10-3 mm 2/ second /.992×10-3 mm /second, P < .01), while there was no correlation between the DTI parameters and the anatomical volumes.
These results suggest that there is more contralateral brain reorganization in HGG patients than MET patients and that neither the tumor nor callosal volume impact the degree of contralateral brain reorganization.
胼胝体（CC）在调节半球间信息传递中起重要作用，并且正如先前一项研究通过扩散张量成像（DTI）特征报告语言优势组之间的胼胝体差异所表明的那样，其被认为在脑肿瘤患者的对侧脑重组中起作用。本研究的目的是利用分数各向异性（FA）、平均扩散率（MD）和轴向扩散率（AD）的DTI特征，探索高级别胶质瘤（HGG）和转移瘤（MET）之间CC的结构差异。
对30例HGG和20例MET患者进行回顾性研究，这些患者均有包括DTI的磁共振成像（MRI）扫描。使用三维T1加权扫描对肿瘤和CC进行分割以确定其体积。将CC体部的感兴趣区（ROI；ROI的平均体积=3,090±464mm）叠加到DTI参数图上，以获得平均FA、MD和AD值。
两组患者之间FA和MD值的分布存在显著差异（HGG/MET的平均FA=.691/.646，P<.05；HGG/MET的平均MD=.894×10-3mm2/秒/.992×10-3mm/秒，P<.01），而DTI参数与解剖体积之间无相关性。
这些结果表明，HGG患者的对侧脑重组比MET患者更多，并且肿瘤和胼胝体体积均不影响对侧脑重组程度。
