Herman Z S
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice.
Pol J Pharmacol Pharm. 1987 Sep-Oct;39(5):633-9.
This paper reviews data concerning the possible role of opioid neuropeptides in the central action of psychotropic drugs. The results summarized provide an evidence that the long term interruption of the central dopaminergic mechanisms by administration of neuroleptics causes specific alterations in the content, release and biosynthesis of several opioid peptides. Moreover, the dynamic changes of the enkephalin level in brain structures after one year of fluphenazine administration were described. The acute and chronic treatment with benzodiazepines induced pronounced changes in brain enkephalin concentrations. The first evidences are provided that chronic antidepressant treatment changes the level of enkephalins in discrete brain areas.
本文综述了有关阿片类神经肽在精神药物中枢作用中可能发挥的作用的数据。总结的结果表明，通过给予抗精神病药物长期中断中枢多巴胺能机制会导致几种阿片肽的含量、释放和生物合成发生特定改变。此外，还描述了给予氟奋乃静一年后脑结构中脑啡肽水平的动态变化。苯二氮䓬类药物的急性和慢性治疗可引起脑内脑啡肽浓度的显著变化。首次有证据表明，慢性抗抑郁治疗会改变离散脑区中脑啡肽的水平。
