Hattori Yoshihide, Ogaki Takuya, Ishimura Miki, Ohta Yoichiro, Kirihata Mitsunori
Research Center of Boron Neutron Capture Therapy, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, Japan.
Sensors (Basel). 2017 Oct 24;17(10):2436. doi: 10.3390/s17102436.
Novel boron-containing drugs have recently been suggested as a new class of pharmaceuticals. However, the majority of current boron-detection techniques require expensive facilities and/or tedious pretreatment methods. Thus, to develop a novel and convenient detection method for boron-based pharmaceuticals, imine-type boron-chelating-ligands were previously synthesized for use in a fluorescent sensor for boronic acid containing compounds. However, the fluorescence quantum yield of the imine-type sensor was particularly low, and the sensor was easily decomposed in aqueous media. Thus, in this paper, we report the development of a novel, convenient, and stable fluorescent boron-sensor based on - and -chelation (i.e., 2-(pyridine-2yl)phenol), and a corresponding method for the quantitative and qualitative detection of boronic acid-containing compounds using this commercially available sensor is presented.
最近，新型含硼药物被提议作为一类新的药物。然而，当前大多数硼检测技术需要昂贵的设备和/或繁琐的预处理方法。因此，为了开发一种用于硼基药物的新型便捷检测方法，之前合成了亚胺型硼螯合配体，用于含硼酸化合物的荧光传感器。然而，亚胺型传感器的荧光量子产率特别低，并且该传感器在水性介质中容易分解。因此，在本文中，我们报告了一种基于 - 和 - 螯合（即2-(吡啶-2-基)苯酚）的新型、便捷且稳定的荧光硼传感器的开发，并提出了使用这种市售传感器对含硼酸化合物进行定量和定性检测的相应方法。
