Chaudhary Preeti Madhukar, Murthy Raghavendra Vasudeva, Yadav Rohan, Kikkeri Raghavendra
Indian Institute of Science Education and Research, Dr. Homi Bhabbha Road, Pashan, Pune 411008, India.
Chem Commun (Camb). 2015 May 11;51(38):8112-5. doi: 10.1039/c5cc01662b. Epub 2015 Apr 14.
We have developed peptidomimetic sialic acid (Sia) biosensors using boronic acid and arginine groups on the peptide backbone. The designed peptides were conjugated to fluorescent streptavidin via biotin enabling the optical labeling of cells. This approach provides unique opportunities to detect Sia composition on the cell surfaces and filopodia.
我们利用肽主链上的硼酸和精氨酸基团开发了拟肽唾液酸（Sia）生物传感器。设计的肽通过生物素与荧光链霉亲和素偶联，实现细胞的光学标记。这种方法为检测细胞表面和丝状伪足上的Sia组成提供了独特的机会。
