蓝精灵转变：动物模型临终研究对衰老的新见解。
The Smurf transition: new insights on ageing from end-of-life studies in animal models.
作者信息
Rera Michael, Vallot Céline, Lefrançois Christel
机构信息
Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR8251 - CNRS - Université Diderot, Sorbonne Paris Cité.
Translational Department 'Dynamics of epigenetic alterations in breast cancer' UMR3244, Institut Curie, Paris.
出版信息
Curr Opin Oncol. 2018 Jan;30(1):38-44. doi: 10.1097/CCO.0000000000000419.
PURPOSE OF REVIEW
Over the past 5 years, many articles were published concerning the prediction of high risk of mortality in apparently healthy adults, echoing the first description in 2011 of the Smurf phenotype, a harbinger of natural death in drosophila.
RECENT FINDINGS
These recent findings suggest that the end-of-life is molecularly and physiologically highly stereotyped, evolutionarily conserved and predictable.
SUMMARY
Taken altogether, these results from independent teams using multiple organisms including humans draw the lines of future directions in ageing research. The ability to identify and study individuals about to die of natural causes with no apparent diseases is a game-changer in this field. In addition, the public health applications are potentially of tremendous impact in our ageing societies and raise important ethical questions.
综述目的
在过去5年里，发表了许多关于预测看似健康的成年人高死亡风险的文章，这呼应了2011年首次描述的蓝精灵表型，它是果蝇自然死亡的先兆。
最新发现
这些最新发现表明，生命终结在分子和生理层面上具有高度的刻板性、进化上保守且可预测。
总结
综合来看，这些来自独立团队、使用包括人类在内的多种生物的研究结果，勾勒出了衰老研究未来的方向。能够识别和研究没有明显疾病却即将自然死亡的个体，是该领域的一个变革。此外，其在公共卫生方面的应用可能会对我们老龄化社会产生巨大影响，并引发重要的伦理问题。
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