PLD 和 PA 让 MT1-MMP 进行转移之旅。
PLD and PA Take MT1-MMP for a Metastatic Ride.
机构信息
University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.
University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.
出版信息
Dev Cell. 2017 Oct 23;43(2):117-119. doi: 10.1016/j.devcel.2017.10.012.
Abstract
Polarized targeting and deposition of MT1-MMP is pivotal for metastasis. In this issue of Developmental Cell, Wang et al. (2017) reveal that a signaling molecule generated by phospholipase D2 drives deposition of MT1-MMP at the site of invadopodia formation and is critical for metastasis in a transgenic breast cancer model.
摘要
极化的 MT1-MMP 靶向和沉积对于转移至关重要。在本期《发育细胞》中，Wang 等人（2017）揭示了由磷脂酶 D2 产生的信号分子驱动 MT1-MMP 在侵袭伪足形成部位的沉积，并且对于转基因乳腺癌模型中的转移是至关重要的。
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