Department of Nephrology, OLVG west, Amsterdam, The Netherlands; Department of Psychiatry, OLVG west, Amsterdam, The Netherlands.
Department of Nephrology, OLVG west, Amsterdam, The Netherlands; Department of Psychiatry, OLVG west, Amsterdam, The Netherlands.
Gen Hosp Psychiatry. 2018 Jan-Feb;50:76-82. doi: 10.1016/j.genhosppsych.2017.10.003. Epub 2017 Oct 13.
Possibly, different biochemical parameters are involved in the development of depressive symptoms in white and non-white dialysis patients. We examined whether the association between inflammation and depressive symptoms and between tryptophan and depressive symptoms differs between white and non-white dialysis patients and whether the association between inflammation and depressive symptoms is mediated by tryptophan degradation along the kynurenine pathway in both groups.
Depressive symptoms were measured with the BDI-II. HsCRP, IL-1β, IL-6, IL-10, and TNFα and tryptophan and its degradation products kynurenine and 3-hydroxykynurenine were measured in 270 white and 220 non-white patients.
The presence of depressive symptoms was significantly higher in non-white patients (51%) than in white patients (37%) (P<0.01). Among white patients, HsCRP was significantly associated with depressive symptoms (β=0.6 (95% CI: 0.1-1.2)). Among non-white patients, significant associations with depressive symptoms were found for both HsCRP (β=1.0 (95% CI: 0.1-2.0)) and IL-6 (β=2.6 (95% CI: 0.8-4.4)). Tryptophan levels were only significantly associated with depressive symptoms in non-white patients (β=-0.3 (95% CI: -0.4--0.1)). Tryptophan degradation along the kynurenine pathway did not mediate the association between inflammatory markers and depressive symptoms in either group.
Our results indicate that for white and non-white dialysis patients different biochemical parameters are associated with depressive symptoms.
可能不同的生化参数参与了白种人和非白种透析患者抑郁症状的发展。我们研究了炎症与抑郁症状之间的关系以及色氨酸与抑郁症状之间的关系在白种人和非白种透析患者中是否存在差异，以及炎症与抑郁症状之间的关系是否沿着犬尿氨酸途径在两组患者中通过色氨酸降解来介导。
使用 BDI-II 评估抑郁症状。在 270 名白种人和 220 名非白种人患者中测量了 HsCRP、IL-1β、IL-6、IL-10 和 TNFα 以及色氨酸及其降解产物犬尿氨酸和 3-羟基犬尿氨酸。
非白种人患者（51%）出现抑郁症状的比例明显高于白种人患者（37%）（P<0.01）。在白种人患者中，HsCRP 与抑郁症状显著相关（β=0.6（95%CI：0.1-1.2））。在非白种人患者中，HsCRP（β=1.0（95%CI：0.1-2.0））和 IL-6（β=2.6（95%CI：0.8-4.4））与抑郁症状均存在显著相关性。只有非白种人患者的色氨酸水平与抑郁症状显著相关（β=-0.3（95%CI：-0.4--0.1））。在两组患者中，色氨酸沿犬尿氨酸途径的降解均未介导炎症标志物与抑郁症状之间的关联。
我们的研究结果表明，对于白种人和非白种透析患者，不同的生化参数与抑郁症状相关。
