Sedaghattalab Moslem, Razazan Marzieh, Shahpari Mohsen, Azarmehr Nahid, Larki Rozina Abbasi, Sadeghi Hossein, Asfaram Arash, Taheri Tahere, Pourshohod Aminollah, Moslemi Zahra, Abbaszadeh-Goudarzi Kazem, Doustimotlagh Amir Hossein
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran.
Biochem Res Int. 2021 May 26;2021:5588464. doi: 10.1155/2021/5588464. eCollection 2021.
Chronic kidney disorder is a main public health concern. Inflammatory processes and oxidative stress are common in end-stage renal disease patients. We aimed to evaluate the effect of the hydroalcoholic extract of watercress (WC) on the inflammatory cytokines and protein carbonyl (PCO) contents in chronic hemodialysis patients.
This was a double-blind randomized clinical trial performed on 46 hemodialysis patients. The participants were randomly divided into two groups: intervention group (500 mg hydroalcoholic extract of WC every day for 4 weeks) and control group (500 mg of white flour every night for 4 weeks). The blood samples were taken to determine the levels of vitamin E, PCO, and inflammatory cytokines at baseline and the end of treatment.
Forty-five patients completed the study (22 patients in the intervention group and 23 patients in the control group). There was a significant reduction in the PCO level (20.33 ± 4.40 vs. 15.06 ± 6.41, =0.001) in the intervention group; also, this change was statistically significant relative to the control group. Furthermore, there were significant reductions in hs-CRP (8953.30 ± 5588.06 vs. 7249.86 ± 5091.62, =0.007) and IL-6 (60.10 (55.99, 73.10) vs. 55.21 (53.39, 60.48), =0.050) in the intervention group, but these changes were not significant in comparison with the control group.
We conclude that the hydroalcoholic extract of WC reduced the PCO content in hemodialysis patients via inhibition of protein oxidation. Although WC administration had caused a significant reduction in IL-6 and CRP levels, these differences were not statistically significant relative to the control group. Further research is needed to identify the antioxidant and anti-inflammatory effects of WC in hemodialysis patients.
慢性肾脏疾病是主要的公共卫生问题。炎症过程和氧化应激在终末期肾病患者中很常见。我们旨在评估豆瓣菜水醇提取物（WC）对慢性血液透析患者炎症细胞因子和蛋白质羰基（PCO）含量的影响。
这是一项对46名血液透析患者进行的双盲随机临床试验。参与者被随机分为两组：干预组（每天服用500毫克WC水醇提取物，共4周）和对照组（每晚服用500毫克白面粉，共4周）。在基线和治疗结束时采集血样，以测定维生素E、PCO和炎症细胞因子水平。
45名患者完成了研究（干预组22名患者，对照组23名患者）。干预组的PCO水平显著降低（20.33±4.40对15.06±6.41，P=0.001）；此外，相对于对照组，这种变化具有统计学意义。此外，干预组的hs-CRP（8953.30±5588.06对7249.86±5091.62，P=0.007）和IL-6（60.10（55.99，73.10）对55.21（53.39，60.48），P=0.050）显著降低，但与对照组相比，这些变化不显著。
我们得出结论，WC水醇提取物通过抑制蛋白质氧化降低了血液透析患者的PCO含量。虽然服用WC导致IL-6和CRP水平显著降低，但相对于对照组，这些差异无统计学意义。需要进一步研究以确定WC在血液透析患者中的抗氧化和抗炎作用。
