Passos da Silva Daniel, Schofield Melissa C, Parsek Matthew R, Tseng Boo Shan
Department of Microbiology, University of Washington School of Medicine, Box 357735, 1959 NE Pacific Street, Seattle, WA 98195-7242, USA.
School of Life Sciences, University of Nevada, Las Vegas Box MS 454004 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA.
Pathogens. 2017 Oct 21;6(4):51. doi: 10.3390/pathogens6040051.
Bacteria are social creatures that are able to interact and coordinate behaviors with each other in a multitude of ways. The study of such group behaviors in microbes was coined "sociomicrobiology" in 2005. Two such group behaviors in bacteria are quorum sensing (QS) and biofilm formation. At a very basic level, QS is the ability to sense bacterial density via cell-to-cell signaling using self-produced signals called autoinducers, and biofilms are aggregates of cells that are attached to one another via a self-produced, extracellular matrix. Since cells in biofilm aggregates are in close proximity, biofilms represent an ecologically relevant environment for QS. While QS is known to affect biofilm formation in both Gram-negative and Gram-positive species, in this review, we will focus exclusively on Gram-negative bacteria, with an emphasis on . We will begin by describing QS systems in and how they affect biofilm formation. We then expand our review to other Gram-negative bacteria and conclude with interesting questions with regard to the effect of biofilms on QS.
细菌是社会性生物，能够通过多种方式相互作用并协调行为。对微生物中此类群体行为的研究在2005年被称为“社会微生物学”。细菌中的两种此类群体行为是群体感应（QS）和生物膜形成。在非常基本的层面上，群体感应是指通过使用称为自诱导物的自身产生的信号进行细胞间信号传导来感知细菌密度的能力，而生物膜是通过自身产生的细胞外基质相互附着的细胞聚集体。由于生物膜聚集体中的细胞彼此靠近，生物膜代表了一个与群体感应在生态上相关的环境。虽然已知群体感应会影响革兰氏阴性菌和革兰氏阳性菌中的生物膜形成，但在本综述中，我们将专门关注革兰氏阴性菌，重点是 。我们将首先描述 中的群体感应系统以及它们如何影响 生物膜形成。然后我们将综述扩展到其他革兰氏阴性菌，并以关于生物膜对群体感应影响的有趣问题作为结尾。
