Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Str., 02-093 Warsaw, Poland.
Int J Mol Sci. 2017 Oct 21;18(10):2207. doi: 10.3390/ijms18102207.
Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics.
微管是由α、β-微管蛋白异二聚体组成的中空管状聚合体结构。它们在许多细胞过程中发挥着重要作用，包括细胞内运输、细胞运动和细胞分裂过程中染色体的分离。此外，微管二联体或三联体分别构成纤毛、中心粒和基体的支架。为了执行如此多样化的功能，微管在其性质上必须有所不同。翻译后修饰是影响微管蛋白聚合物性质的因素之一。在这里，我们重点介绍翻译后修饰对微管动力学的直接和间接影响。
