Namli Kalem Muberra, Kalem Ziya, Akgun Nilufer, Yuce Ebru, Aktas Hatice
a Department of Obstetrics and Gynecology , Liv Hospital , Ankara , Turkey.
b Gurgan Clinic, IVF , Ankara , Turkey.
J Matern Fetal Neonatal Med. 2019 Mar;32(6):954-960. doi: 10.1080/14767058.2017.1396311. Epub 2017 Nov 6.
The aim of this study was to investigate the possible maternal and fetal factors, which affect the Umbilical Coiling Index (UCI).
This prospective, observational, analytic study was conducted using the data of 380 women with term pregnancy and newborns who presented at a University Hospital. Hemoglobin (Hb), ferritin, iron, and the total iron binding capacity (TIBC) of the maternal blood were measured, and transferrin saturation was estimated based on the ratio between serum iron and TIBC. Blood gases, ferritin, iron, and TIBC of the umbilical cord were also measured, and the transferrin saturation was calculated. The length and thickness of the umbilical cord, numbers of coilings, weight of placenta, neonatal weight were registered. The UCI was calculated dividing the total number of coils by the length of the umbilical cord (in cm).
A positive, linear, and statistically significant relationship was found between the UCI scores and the umbilical cord blood transferrin saturation, umbilical cord thickness, and the first- and fifth-min APGAR scores (p = .044, p < .001, p = .008, p = .022, respectively). No statistically significant relationship was found between the maternal Hb values and the UCI scores (p = .472). In addition, there was no statistically significant relationship between the UCI scores and maternal ferritin, maternal transferrin saturation and umbilical cordon ferritin levels (p = .940, p = .681, and p = .975, respectively).
A positive correlation was found between the UCI and umbilical cord transferrin saturation and between the newborn APGAR scores. However, this finding is not sufficient to explain the relationship of the umbilical cord dynamics with the newborn wellbeing and coiling.
本研究旨在调查可能影响脐带盘绕指数（UCI）的母体和胎儿因素。
本前瞻性、观察性、分析性研究使用了在一家大学医院就诊的380名足月妊娠妇女及其新生儿的数据。测量母体血液中的血红蛋白（Hb）、铁蛋白、铁和总铁结合力（TIBC），并根据血清铁与TIBC的比值估算转铁蛋白饱和度。还测量了脐带的血气、铁蛋白、铁和TIBC，并计算转铁蛋白饱和度。记录脐带的长度和厚度、盘绕数、胎盘重量、新生儿体重。通过将总盘绕数除以脐带长度（以厘米为单位）来计算UCI。
发现UCI评分与脐带血转铁蛋白饱和度、脐带厚度以及第一分钟和第五分钟的阿氏评分之间存在正相关、线性且具有统计学意义的关系（分别为p = 0.044、p < 0.001、p = 0.008、p = 0.022）。母体Hb值与UCI评分之间未发现统计学意义上的关系（p = 0.472）。此外，UCI评分与母体铁蛋白、母体转铁蛋白饱和度和脐带铁蛋白水平之间也未发现统计学意义上的关系（分别为p = 0.940、p = 0.681和p = 0.975）。
发现UCI与脐带转铁蛋白饱和度以及新生儿阿氏评分之间存在正相关。然而，这一发现不足以解释脐带动态与新生儿健康和盘绕之间的关系。
