Jaillais Anaïs, Herber-Mayne Anne, D'Alteroche Louis, Landau Alain, Merrouche Yacine, Vignot Stéphane
Hôpital Louis-Pasteur, service oncologie-hématologie, 6, rue Claude-Bernard, 28630 Chartres-le-Coudray, France.
Hôpital Louis-Pasteur, service d'hépatogastroentérologie, 6, rue Claude-Bernard, 28630 Chartres-le-Coudray, France.
Bull Cancer. 2018 Feb;105(2):162-170. doi: 10.1016/j.bulcan.2017.09.003. Epub 2017 Oct 22.
Patients with chronic hepatitis B infection are at risk of viral reactivation when treated by immuno- or chemotherapy, with potentially serious or even fatal consequences. This article proposes an overview on screening strategies and antiviral treatment recommendations for oncology patients. We have learned in hematology that reactivations are commun with rituximab and prophylactic treatment is recommanded for any patient who has been in contact with the virus. The risk appears to be lower with cytotoxics but has been far less studied. The recommandations are not formally consensual and upcoming studies will help to establish clearer practice guidelines.
慢性乙型肝炎感染患者在接受免疫治疗或化疗时存在病毒再激活的风险,可能会产生严重甚至致命的后果。本文概述了肿瘤患者的筛查策略和抗病毒治疗建议。我们在血液学领域了解到,使用利妥昔单抗时再激活很常见,任何接触过该病毒的患者都建议进行预防性治疗。细胞毒性药物导致病毒再激活的风险似乎较低,但相关研究要少得多。这些建议尚未达成正式共识,未来的研究将有助于制定更明确的实践指南。