Zhang Yaxin, Chen Yujing, Ma Lina
Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing Institute of Geriatrics, China National Clinical Research Center for Geriatric Disorders, Beijing 100053, China.
Department of Traditional Chinese Medicine, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.
J Clin Neurosci. 2018 Jan;47:1-5. doi: 10.1016/j.jocn.2017.09.022. Epub 2017 Oct 21.
Geriatric depression is a major public health problem and has an especially large effect on health when comorbid with a chronic medical condition. Hypertension, coronary heart disease, and diabetes are accompanied by a high incidence of depression and can affect the treatment and prognosis. Depression is a highly prevalent risk factor for incident of and is associated with morbidity and mortality of cardiovascular disease. In addition to the proactive and effective control of primary diseases, efforts should also be made to improve patients' psychological and social function. Current evidence on antidepressive therapy in patients with coronary diseases is limited. A better understanding of pathophysiological mechanisms underpinning depression and cardiovascular disease as well as the complex biological crosstalk of cardiovascular disease complicated with depression is particularly important for future therapeutic strategies. The following review is on current understanding of geriatric depression and cardiovascular disease.
老年抑郁症是一个重大的公共卫生问题，当与慢性疾病合并存在时，对健康的影响尤为巨大。高血压、冠心病和糖尿病伴有较高的抑郁症发病率，并且会影响治疗和预后。抑郁症是心血管疾病发病的一个高度普遍的危险因素，且与心血管疾病的发病率和死亡率相关。除了积极有效地控制原发性疾病外，还应努力改善患者的心理和社会功能。目前关于冠心病患者抗抑郁治疗的证据有限。更好地理解抑郁症和心血管疾病的病理生理机制以及心血管疾病合并抑郁症的复杂生物学相互作用对于未来的治疗策略尤为重要。以下综述是关于目前对老年抑郁症和心血管疾病的认识。
