School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
Microb Pathog. 2017 Dec;113:102-106. doi: 10.1016/j.micpath.2017.10.035. Epub 2017 Oct 21.
We evaluate the role of antioxidant enzyme status and inflammatory cascade in disease progression of cystitis in a rat model. The animals were injected with clinically isolated Uropathogenic Escherichia coli (UPEC) and study the effect of various antioxidant enzymes and inflammatory markers in disease pathology on the 0 day, 12 h and 7 day of infection. The antioxidant status of bladder tissue was decreased during the 7 day of infection. Lipid peroxidation marker MDA was increased on the 7 day of infection in rats. The histopathology of bladder tissue shows severe inflammation and edema. This study reveals the role of decreased antioxidant status during infection play a vital role in upregulation of inflammation and tissue destruction.
我们评估了抗氧化酶状态和炎症级联在膀胱炎疾病进展中的作用，建立了大鼠模型。动物被注射临床分离的尿路致病性大肠杆菌（UPEC），研究了在感染的第 0 天、12 小时和 7 天，各种抗氧化酶和炎症标志物对疾病病理的影响。在感染的第 7 天，膀胱组织的抗氧化状态下降。脂质过氧化标志物 MDA 在感染第 7 天的大鼠中增加。膀胱组织的组织病理学显示出严重的炎症和水肿。这项研究揭示了感染期间抗氧化状态的下降在炎症和组织破坏的上调中起着至关重要的作用。
