甲状腺抗氧化状态的特点。

Peculiarities of the antioxidant status of the thyroid gland.

作者信息

Nadolnik L I, Valentyukevich O I

机构信息

Research-and-Production Center, Institute of Pharmacology and Biochemistry, Belarussian Academy of Sciences, Grodno.

出版信息

Bull Exp Biol Med. 2007 Oct;144(4):529-31. doi: 10.1007/s10517-007-0369-3.

DOI:10.1007/s10517-007-0369-3

PMID:18642705

Abstract

The intensity of lipid peroxidation and activity of the antioxidant system in the thyroid gland were compared with those in the liver, kidney, heart, and frontal lobes of the cerebral hemispheres in euthyroid male Wistar rats. The thyroid gland was characterized by low activity of first-line antioxidant enzymes superoxide dismutase and catalase, considerable concentration of reduced glutathione, and high activity of glutathione peroxidase and glutathione reductase. Our results suggest that the system of glutathione metabolism determines antioxidant status of the thyroid gland.

摘要

在甲状腺功能正常的雄性Wistar大鼠中，比较了甲状腺中脂质过氧化强度和抗氧化系统活性与肝脏、肾脏、心脏及大脑半球额叶中的相应指标。甲状腺的特征在于一线抗氧化酶超氧化物歧化酶和过氧化氢酶活性较低、还原型谷胱甘肽浓度较高，以及谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性较高。我们的结果表明，谷胱甘肽代谢系统决定了甲状腺的抗氧化状态。