Fardy J M, Lloyd D A, Reynolds R P
Department of Medicine, St. Joseph's Health Centre, London, Ontario, Canada.
J Clin Gastroenterol. 1988 Dec;10(6):635-7. doi: 10.1097/00004836-198812000-00012.
Two patients with ulcerative colitis and a past history of allergic reactions to sulfasalazine had similar reactions when treated with 5-aminosalicylic acid. This suggests that, at least in some patients, the adverse effects of sulfasalazine are due to 5-aminosalicylic acid rather than sulfapyridine. Desensitization to sulfasalazine was successfully carried out in one patient but was not attempted in a second.
两名患有溃疡性结肠炎且既往对柳氮磺胺吡啶有过敏反应的患者，在接受5-氨基水杨酸治疗时出现了类似反应。这表明，至少在某些患者中，柳氮磺胺吡啶的不良反应是由5-氨基水杨酸而非磺胺吡啶引起的。一名患者成功进行了柳氮磺胺吡啶脱敏治疗，但第二名患者未尝试。
