维生素D受体ApaI（rs7975232）多态性降低总体人群及非洲人群患肺结核的风险，但在亚洲人群中并非如此：一项荟萃分析的证据

Vitamin D Receptor ApaI (rs7975232) Polymorphism Confers Decreased Risk of Pulmonary Tuberculosis in Overall and African Population, but not in Asians: Evidence from a Meta-analysis.

作者信息

Areeshi Mohammed Y, Mandal Raju K, Wahid Mohd, Dar Sajad A, Jawed Arshad, Lohani Mohtashim, Abdallah Amir Mahgoub Awadelkareem, Khan Saif, Panda Aditya K, Mishra B N, Haque Shafiul

机构信息

Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.

Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi, India.

出版信息

Ann Clin Lab Sci. 2017 Sep;47(5):628-637.

PMID:29066494

Abstract

GOALS

The involvement of the VDR ApaI gene polymorphism in the development of pulmonary tuberculosis (PTB) has been reported by numerous published studies and yielded inconsistent results. The present meta-analysis evaluated the association of VDR ApaI polymorphism and risk of PTB occurrence.

PROCEDURES

PubMed (Medline), EMBASE and Google Scholar web-databases were searched and a meta-analysis was performed by calculating the pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).

RESULTS

This meta-analysis included a total of 14 eligible studies comprising of 1958 confirmed PTB cases and 2938 controls. We observed decreased risk of PTB in allelic (a vs. A: =0.003; OR=0.873, 95% CI=0.798 to 0.955), homozygous (aa vs. AA: =0.006; OR=0.761, 95% CI=0.626 to 0.924), dominant (aa+Aa vs. AA: =0.039; OR=0.874, 95% CI=0.769 to 0.993) and recessive (aa vs. AA+Aa: =0.025; OR=0.819, 95% CI=0.688 to 0.975) genetic models. During subgroup analysis, allele (a vs. A: =0.005; OR=0.846, 95% CI=0.753 to 0.951), homozygous (aa vs. AA: =0.002; OR=0.662, 95% CI=0.513 to 0.854) and recessive genetic models (aa vs. AA+Aa: p=0.003; OR=0.709, 95% CI=0.566 to 0.889) demonstrated decreased PTB risk in African population. However, no significant association was observed in Asian population.

CONCLUSION

In conclusion, VDR ApaI polymorphism is significantly associated with decreased risk of PTB for in overall and African population, but not in Asians.

摘要

目标

众多已发表的研究报道了维生素D受体（VDR）ApaI基因多态性与肺结核（PTB）发病之间的关联，但结果并不一致。本荟萃分析评估了VDR ApaI多态性与PTB发病风险的关联。

方法

检索了PubMed（Medline）、EMBASE和谷歌学术数据库，并通过计算合并比值比（OR）和95%置信区间（95%CI）进行荟萃分析。

结果

本荟萃分析共纳入14项符合条件的研究，包括1958例确诊的PTB病例和2938例对照。我们观察到在等位基因（a与A相比：P=0.003；OR=0.873，95%CI=0.798至0.955）、纯合子（aa与AA相比：P=0.006；OR=0.761，95%CI=0.626至0.924）、显性（aa+Aa与AA相比：P=0.039；OR=0.874，95%CI=0.769至0.993）和隐性（aa与AA+Aa相比：P=0.025；OR=0.819，95%CI=0.688至0.975）遗传模型中PTB风险降低。在亚组分析中，等位基因（a与A相比：P=0.005；OR=0.846，95%CI=0.753至0.951）、纯合子（aa与AA相比：P=0.002；OR=0.662，95%CI=0.513至0.854）和隐性遗传模型（aa与AA+Aa相比：P=0.003；OR=0.709，95%CI=0.566至0.889）显示非洲人群中PTB风险降低。然而，在亚洲人群中未观察到显著关联。