Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
The University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi 110095, India.
Biosci Rep. 2017 Oct 27;37(5). doi: 10.1042/BSR20170240. Print 2017 Oct 31.
Earlier studies have shown that () -1082 A>G gene polymorphism is implicated in susceptibility to pulmonary tuberculosis (PTB), but their results are inconsistent and inconclusive. In the present study, a meta-analysis was performed to analyze the potential association between -1082 A>G gene polymorphism and PTB susceptibility.
A quantitative synthesis was done using PubMed (Medline), EMBASE, and Google Scholar web databases search and meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models.
A total of 22 eligible studies comprising 4956 PTB cases and 6428 healthy controls were included in the analysis. We did not observe any increased or decreased risk of PTB in allelic contrast (G vs. A: =0.985; OR = 1.001, 95% CI = 0.863-1.162), homozygous (GG vs. AA: =0.889; OR = 1.029, 95% CI = 0.692-1.529), heterozygous (GA vs. AA: =0.244; OR = 0.906, 95% CI = 0.767-1.070), dominant (GG + AG vs. AA: =0.357; OR = 1.196, 95% CI = 0.817-1.752), and recessive (GG vs. AA + AG: =0.364; OR = 0.921, 95% CI = 0.771-1.100) genetic models. Likewise, no association of -1082 A>G polymorphism with PTB risk was observed in Asian and African population for all the genetic models. Interestingly, the dominant model (GG + AG vs. AA: =0.004; OR = 1.694, 95% CI = 1.183-2.425) demonstrated increased risk of PTB in Caucasian population.
This meta-analysis concludes that -1082 A>G gene polymorphism is not significantly associated with overall, Asian and African population. However, this polymorphism is associated with Caucasian population.
先前的研究表明， -1082A>G 基因多态性与肺结核（PTB）易感性有关，但结果不一致，尚无定论。本研究采用荟萃分析方法，分析 -1082A>G 基因多态性与 PTB 易感性的潜在关联。
通过 PubMed（Medline）、EMBASE 和 Google Scholar 网络数据库进行定量综合，并通过计算所有遗传模型的合并优势比（ORs）和 95%置信区间（95%CI）进行荟萃分析。
共纳入 22 项符合条件的研究，包括 4956 例 PTB 病例和 6428 例健康对照。我们未发现等位基因对比（G 对 A： =0.985；OR = 1.001，95%CI = 0.863-1.162）、纯合子（GG 对 AA： =0.889；OR = 1.029，95%CI = 0.692-1.529）、杂合子（GA 对 AA： =0.244；OR = 0.906，95%CI = 0.767-1.070）、显性（GG + AG 对 AA： =0.357；OR = 1.196，95%CI = 0.817-1.752）和隐性（GG 对 AA + AG： =0.364；OR = 0.921，95%CI = 0.771-1.100）遗传模型中 PTB 的风险增加或降低。同样，在所有遗传模型中， -1082A>G 多态性与亚洲和非洲人群的 PTB 风险也无关联。有趣的是，在高加索人群中，显性模型（GG + AG 对 AA： =0.004；OR = 1.694，95%CI = 1.183-2.425）显示出 PTB 的风险增加。
本荟萃分析表明， -1082A>G 基因多态性与总体人群、亚洲人群和非洲人群无显著关联。然而，这种多态性与高加索人群有关。
