Division of Infection and Immunity, University College London, London, England, UK.
Division of Infection and Immunity, University College London, London, England, UK
J Cell Biol. 2017 Nov 6;216(11):3429-3431. doi: 10.1083/jcb.201710068. Epub 2017 Oct 24.
Cancer cells thrive on genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid immune recognition. In this issue, Cuellar et al. (2017. https://doi.org/10.1083/jcb.201612160) find that the histone methyltransferase SETDB1 enables acute myeloid leukemia cells to evade sensing of retrotransposons by innate immune receptors.
癌细胞在遗传和表观遗传变化中茁壮成长，这些变化赋予了它们选择性优势，但它们也需要策略来避免免疫识别。在本期杂志中，Cuellar 等人（2017. https://doi.org/10.1083/jcb.201612160）发现组蛋白甲基转移酶 SETDB1 使急性髓系白血病细胞能够逃避先天免疫受体对反转录转座子的感知。
