Warren J B, Dollery C T
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, UK.
J Hypertens Suppl. 1988 Dec;6(2):S43-9.
The development of selective peripheral alpha 1-adrenoceptor antagonists such as prazosin has produced a valuable class of antihypertensive agents. Side effects of fluid retention and reflex sympathetic stimulation usually limit these agents to third-line therapy but their combination with a beta-receptor antagonist and a diuretic provides a powerful regimen. Alpha-adrenoceptor antagonists are useful in patients with conditions such as gout, diabetes or bronchospasm which preclude the use of other agents. Although many new drugs are being developed, little information is available yet on the long-term outcome of therapy with this class of drugs for patients with hypertension.
选择性外周α1肾上腺素能受体拮抗剂（如哌唑嗪）的研发产生了一类有价值的抗高血压药物。液体潴留和反射性交感神经刺激等副作用通常使这些药物仅限于三线治疗，但它们与β受体拮抗剂和利尿剂联合使用可提供一种强效治疗方案。α肾上腺素能受体拮抗剂对患有痛风、糖尿病或支气管痉挛等疾病而不能使用其他药物的患者有用。尽管正在研发许多新药，但关于这类药物用于高血压患者的长期治疗结果的信息仍然很少。
