Doyle A E
Department of Physiology, University of Melbourne, Parkville, Australia.
J Hypertens Suppl. 1988 Dec;6(2):S51-3.
Alpha-blocking drugs, although effective antihypertensive agents, often cause tachycardia, faintness and postural hypotension. Hybrid drugs such as labetalol, which has beta- as well as alpha-blocking action, ketanserin, which has 5-hydroxytryptamine (5HT)-blocking as well as alpha-blocking action, and urapidil, which appears to have a central effect as well as an alpha-blocking action, produce fewer side effects attributable to alpha-blockade. Urapidil appears to be an effective antihypertensive drug with a wide spectrum of action and few side effects.
α受体阻断药虽然是有效的抗高血压药物，但常引起心动过速、头晕和体位性低血压。具有β受体和α受体阻断作用的拉贝洛尔、具有5-羟色胺（5HT）阻断和α受体阻断作用的酮色林以及似乎具有中枢作用和α受体阻断作用的乌拉地尔等混合药物，产生的α受体阻断相关副作用较少。乌拉地尔似乎是一种作用广泛且副作用少的有效抗高血压药物。
