Sista Swathi K, Arum Seth M
Division of Endocrinology, Diabetes, and Metabolism, University of Massachusetts, 55 Lake Avenue North, Worcester, MA 01655, USA.
J Clin Transl Endocrinol. 2016 Jul 25;5:32-35. doi: 10.1016/j.jcte.2016.07.002. eCollection 2016 Sep.
The Kidney Disease: Improving Global Outcomes (KDIGO) work group released recommendations in 2006 to define the bone-related pathology associated with chronic kidney disease as renal osteodystrophy. In 2009, KDIGO released revised clinical practice guidelines which redefined systemic disorders of bone and mineral metabolism due to chronic kidney disease as chronic kidney disease-mineral and bone disorders. Conditions under this overarching term include osteitis fibrosa cystica, osteomalacia, and adynamic bone disease. We aim to provide a brief review of the histopathology, pathophysiology, epidemiology, and diagnostic features of adynamic bone disease, focusing on current trends in the management of this complex bone disorder.
改善全球预后（KDIGO）工作组在2006年发布了相关建议，将与慢性肾脏病相关的骨病理改变定义为肾性骨营养不良。2009年，KDIGO发布了修订后的临床实践指南，将慢性肾脏病所致的骨与矿物质代谢系统性紊乱重新定义为慢性肾脏病-矿物质和骨异常。这一总体术语涵盖的病症包括纤维囊性骨炎、骨软化症和骨转化动力缺乏型骨病。我们旨在简要综述骨转化动力缺乏型骨病的组织病理学、病理生理学、流行病学及诊断特征，重点关注这一复杂骨病管理方面的当前趋势。
