Department of Psychology, Rice University, Houston, TX, USA.
Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA.
J Behav Med. 2018 Jun;41(3):333-343. doi: 10.1007/s10865-017-9895-2. Epub 2017 Oct 24.
Individuals with a history of poor interpersonal relationships are more likely to demonstrate negative health outcomes than those who have had high quality relationships. We sought to evaluate how attachment orientations, stress-induced respiratory sinus arrhythmia (RSA), and self-reported stress were associated with length of telomeres measured from peripheral blood mononuclear cells. Participants (N = 213) completed self-report measures of attachment and stress. Measurement of RSA was conducted before and after a stressful task and a blood draw was completed for analysis of telomere length. Attachment orientations were not directly associated with telomere length; however, we found that high attachment anxiety was associated with shorter length of telomeres via high self-reported stress. Attachment avoidance was also associated with telomere length via self-reported stress, but only among those with high stress-induced RSA. Exploratory analyses of T cell subsets indicated that stress was most strongly associated with telomeres from CD8CD28+ cells in comparison to CD8CD28- and CD4 cells. Study findings indicate that attachment orientations are associated with telomere length via stress, providing novel insights into the mechanisms through which close relationships can impact health and aging.
人际关系差的个体比人际关系良好的个体更有可能出现健康状况不佳的结果。我们试图评估依恋取向、应激诱导的呼吸窦性心律失常（RSA）和自我报告的应激与从外周血单核细胞测量的端粒长度之间的关系。参与者（N=213）完成了依恋和应激的自我报告测量。在进行应激任务前后测量 RSA，并完成血液采集以分析端粒长度。依恋取向与端粒长度没有直接关系；然而，我们发现高依恋焦虑通过高自我报告的应激与较短的端粒长度相关。回避型依恋也通过自我报告的应激与端粒长度相关，但仅在应激诱导的 RSA 较高的个体中。T 细胞亚群的探索性分析表明，与 CD8CD28-和 CD4 细胞相比，应激与 CD8CD28+细胞的端粒关系最密切。研究结果表明，依恋取向通过应激与端粒长度相关，为亲密关系如何影响健康和衰老的机制提供了新的见解。
