精准医学进展：定制个性化疗法。
Advances in Precision Medicine: Tailoring Individualized Therapies.
作者信息
Matchett Kyle B, Lynam-Lennon Niamh, Watson R William, Brown James A L
机构信息
Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, College Green, Dublin 2, D08 W9RT, Ireland.
出版信息
Cancers (Basel). 2017 Oct 25;9(11):146. doi: 10.3390/cancers9110146.
Abstract
The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.
摘要
传统的从 bench 到 bedside 的流程包括使用模型系统和患者样本，以深入了解癌症中失调的通路。这一发现揭示了新的生物标志物和治疗靶点，最终对患者进行分层并为基于队列的治疗选择提供依据。精准医学（将个体肿瘤的分子分析与既定的临床病理参数相结合）实时揭示个体患者的诊断和预后风险概况，为量身定制的肿瘤特异性治疗计划提供依据。在此，我们讨论在爱尔兰癌症研究协会年会上展示的精准医学进展，重点介绍个性化医学方法在个体肿瘤中实现精准发现并为定制治疗方案提供依据的实例。
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