Sun Jun, Zhang Ru-Ming, Zheng Yu-Xin
Department of Orthopedics, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Adv Clin Exp Med. 2017 Aug;26(5):781-787. doi: 10.17219/acem/63744.
Malignant fibrous histiocytoma (MFH) of the bone is a rare tumor. Most studies comparing limb salvage and amputation have reported that limb salvage had no adverse effect on the long-term survival of patients. This study evaluates the oncological outcomes of limb salvage procedures that were used for 15 patients with MFH of the humerus.
The aim of this study was to assess the functional and oncological outcomes of patients with malignant fibrous histiocytoma of the humerus after en bloc resection and prosthesis implantation.
A retrospective review of the charts of 15 patients who had undergone resection of malignant fibrous histiocytoma of the humerus followed by reconstruction with prosthesis was used in this study. A functional evaluation was based on Enneking's modified system of the functional evaluation of surgical management for musculoskeletal tumors. Complications of the procedures were also analyzed.
Eight men and 7 women at an average age of 52.9 years were included in the study. The tumor involved the distal humerus in 3 patients, the proximal humerus in 8 patients and the mid-shaft humerus in 4 patients. Excellent results were achieved in 4 patients, good to fair in 10 and poor in 1. One patient had local recurrence. Pulmonary metastases occurred in 6 patients.
Limb salvage surgery with chemotherapy is a viable treatment option for patients with malignant fibrous histiocytoma of the humerus.
骨恶性纤维组织细胞瘤（MFH）是一种罕见的肿瘤。大多数比较保肢和截肢的研究报告称，保肢对患者的长期生存没有不利影响。本研究评估了用于15例肱骨MFH患者的保肢手术的肿瘤学结果。
本研究的目的是评估肱骨恶性纤维组织细胞瘤患者在整块切除和假体植入后的功能和肿瘤学结果。
本研究对15例行肱骨恶性纤维组织细胞瘤切除并假体重建的患者的病历进行了回顾性分析。功能评估基于Enneking改良的肌肉骨骼肿瘤手术治疗功能评估系统。还分析了手术并发症。
研究纳入了8名男性和7名女性，平均年龄52.9岁。3例患者肿瘤累及肱骨远端，8例累及肱骨近端，4例累及肱骨干中段。4例患者结果优秀，10例良好至中等，1例差。1例患者出现局部复发。6例患者发生肺转移。
保肢手术联合化疗是肱骨恶性纤维组织细胞瘤患者可行的治疗选择。
