Iwanejko Małgorzata, Turno-Kręcicka Anna, Tomczyk-Socha Martyna, Kaczorowski Kamil, Grzybowski Andrzej, Misiuk-Hojło Marta
Department and Clinic of Ophthalmology, Wroclaw Medical University, Poland.
Department of Ophthalmology, Poznan City Hospital, Poznań, Poland.
Adv Clin Exp Med. 2017 Aug;26(5):795-801. doi: 10.17219/acem/64023.
Pseudoexfoliation syndrome (PEX) is the most frequently identifiable cause of secondary open-angle glaucoma, known as pseudoexfoliation glaucoma. The exact pathophysiology and etiology of PEX and associated glaucoma remains obscure.
The purpose of this study was to determine the differences in the morphology of the anterior chamber angle in people with pseudoexfoliation syndrome and pseudoexfoliation glaucoma compared to a control group. We also evaluated the correlation between intraocular pressure (IOP) and pigmentation of the angle with the amount of exfoliated material in the anterior segment.
The study group was composed of 155 eyes from 103 patients aged between 43 and 86 years. Each patient underwent a complete ophthalmological examination.
Some difference was found in intraocular pressure between the PEX group and the control group and between the pseudoexfoliation glaucoma group and the control group, but no significant difference was found between the 2 study groups. There was a significant difference in the incidence of some degree of pigmentation in the anterior chamber angle and no difference in the widths of the angle between each group. A significant positive relationship was observed between intraocular pressure and the degree of pigmentation of the anterior chamber angle in both the PEX group and the pseudoexfoliation glaucoma group.
The results of this study indicate that the amount of pigmentation and exfoliation material in the anterior segment significantly correlates with the level of IOP and possibly with the degree of trabecular dysfunction. It seems that for clear identification of PEX and pseudoexfoliation glaucoma factors, clinical assessment appears to be insufficient.
假性剥脱综合征（PEX）是继发性开角型青光眼（即假性剥脱性青光眼）最常见的可识别病因。PEX及相关青光眼的确切病理生理学和病因仍不清楚。
本研究旨在确定假性剥脱综合征和假性剥脱性青光眼患者与对照组相比前房角形态的差异。我们还评估了眼压（IOP）和房角色素沉着与眼前节剥脱物质数量之间的相关性。
研究组由103例年龄在43至86岁之间患者的155只眼睛组成。每位患者均接受了全面的眼科检查。
PEX组与对照组之间以及假性剥脱性青光眼组与对照组之间眼压存在一些差异，但两个研究组之间未发现显著差异。前房角某种程度色素沉着的发生率存在显著差异，而每组房角宽度无差异。在PEX组和假性剥脱性青光眼组中，眼压与前房角色素沉着程度之间均观察到显著的正相关关系。
本研究结果表明，眼前节色素沉着和剥脱物质的数量与眼压水平显著相关，可能还与小梁功能障碍程度相关。似乎对于明确识别PEX和假性剥脱性青光眼因素而言，临床评估似乎并不充分。
