From the Farabi Eye Hospital (M.M., M.J., Y.E., S.M., R.Z., G.F., M.S.), Tehran University of Medical Sciences, Tehran, Iran.
From the Farabi Eye Hospital (M.M., M.J., Y.E., S.M., R.Z., G.F., M.S.), Tehran University of Medical Sciences, Tehran, Iran; The Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Am J Ophthalmol. 2022 Feb;234:199-204. doi: 10.1016/j.ajo.2021.07.025. Epub 2021 Jul 28.
To compare anterior segment and angle parameters between pseudoexfoliation syndrome (PEX) and PEX glaucoma (PEXG) and normal control subjects using anterior segment optical coherence tomography (AS-OCT) imaging.
Cross-sectional study.
One hundred and two subjects with PEXG, PEX, and normal eyes as the control group were recruited from an academic referral institution. All subjects underwent a complete ophthalmologic examination, axial length measurement, and AS-OCT imaging. Anterior segment and angle parameters were evaluated.
After excluding 4 eyes because of poor imaging of the scleral spur, data from 34 eyes with PEXG, 33 eyes with PEX, and 31 eyes of normal control subjects were analyzed. Anterior chamber depth was significantly shallower in eyes with PEXG compared with eyes of control subjects (P < .001). The differences in anterior chamber angle parameters (AOD500, AOD750, TISA500,and TISA750) were significant among study groups, with lower values in the PEXG group compared with the PEX and control subject groups. Lens vault (mean [mm]±SD) was higher in the PEXG (0.46 ±0.21) and PEX (0.427 +0.28) groups compared with the control group (0.305+ 0.20).
PEXG eyes have the narrowest anterior chamber angle parameters. There is a progressive decrease in angle parameters from control subjects to the PEX group to the PEXG group. Narrow anterior chamber angle and anterior chamber depth may have a role in the progression of PEX to PEXG. Detection of narrow angle in these patients may help clinicians manage the disease more properly.
使用眼前节光学相干断层扫描（AS-OCT）成像比较假性剥脱综合征（PEX）和 PEX 青光眼（PEXG）与正常对照组的眼前节和房角参数。
横断面研究。
从一所学术转诊机构招募了 102 例 PEXG、PEX 和正常对照组的患者。所有患者均接受全面眼科检查、眼轴长度测量和 AS-OCT 成像。评估眼前节和房角参数。
排除 4 只因巩膜突成像不佳的眼后，分析了 34 只 PEXG 眼、33 只 PEX 眼和 31 只正常对照组的眼。与对照组相比，PEXG 眼的前房深度明显较浅（P <.001）。房角参数（AOD500、AOD750、TISA500 和 TISA750）在各组之间存在显著差异，PEXG 组的这些参数值均低于 PEX 和对照组。PEXG（0.46 ±0.21）和 PEX（0.427 ±0.28）组的晶状体拱高（平均值[mm]±SD）均高于对照组（0.305 ±0.20）。
PEXG 眼的前房角参数最窄。从对照组到 PEX 组再到 PEXG 组，房角参数逐渐降低。窄前房角和前房深度可能在 PEX 进展为 PEXG 中起作用。在这些患者中检测到窄角可能有助于临床医生更恰当地管理疾病。
