原发性和继发性干燥综合征患者血清细胞间黏附分子-1、血管细胞黏附分子-1和E-选择素水平

Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren's syndrome.

作者信息

Błochowiak Katarzyna J, Olewicz-Gawlik Anna, Trzybulska Dorota, Nowak-Gabryel Michalina, Kocięcki Jarosław, Witmanowski Henryk, Sokalski Jerzy

机构信息

Department of Oral Surgery, Poznan University of Medical Sciences, Poland.

Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland.

出版信息

Adv Clin Exp Med. 2017 Aug;26(5):835-842. doi: 10.17219/acem/61434.

DOI:10.17219/acem/61434

PMID:29068581

Abstract

BACKGROUND

Typical features of Sjögren's syndrome (SS) are severe xerostomia and xerophthalmia which are basic diagnostic criteria.

OBJECTIVES

The aim of this study was to compare the serum levels of soluble (s) intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1) and sE-selectin between primary (pSS), secondary (sSS) and healthy subjects (HS). We correlated these results with selected clinical parameters of disease activity and parameters of the severity of xerostomia and xerophthalmia.

MATERIAL AND METHODS

The serum levels of sICAM-1, sVCAM-1 and sE-selectin were determined by enzyme-linked immunosorbent assay (ELISA) in 16 patients with pSS, 18 with sSS and 15 HS. Eye dryness and xerostomia were assessed by the Schirmer's test, the Fox test and the visual analogue scale (VAS).

RESULTS

The levels of sICAM-1 in pSS and sVCAM-1 in sSS patients were significantly higher when compared to HS (p = 0.02 and p = 0.048, respectively). There were no differences between pSS and sSS. In pSS, sVCAM-1 correlated positively with VAS (rS = 0.52, p = 0.04) and the Fox test (rS = 0.66, p=0.01). In sSS, sE-selectin correlated positively with sICAM-1 (rS = 0.54, p = 0.01), the duration of the disease (rS = 0.51, p = 0.03) and negatively with the Schirmer's test (rS = 0.59, p = 0.04). sICAM-1 correlated positively with the erythrocyte sedimentation rate (ESR) value (rS = 0.59, p = 0.01).

CONCLUSIONS

sVCAM-1 reflects xerostomia in pSS. sICAM-1 and sE-selectin may be additional parameters of sSS activity.

摘要

背景

干燥综合征（SS）的典型特征是严重的口干和眼干，这是基本的诊断标准。

目的

本研究旨在比较原发性干燥综合征（pSS）、继发性干燥综合征（sSS）患者与健康受试者（HS）血清中可溶性（s）细胞间黏附分子1（sICAM-1）、血管细胞黏附分子1（sVCAM-1）和sE-选择素的水平。我们将这些结果与疾病活动的选定临床参数以及口干和眼干的严重程度参数进行关联。

材料与方法

采用酶联免疫吸附测定（ELISA）法测定16例pSS患者、18例sSS患者和15例HS血清中sICAM-1、sVCAM-1和sE-选择素的水平。通过施默试验、福克斯试验和视觉模拟评分法（VAS）评估眼干和口干情况。

结果

与HS相比，pSS患者的sICAM-1水平和sSS患者的sVCAM-1水平显著更高（分别为p = 0.02和p = 0.048）。pSS和sSS之间无差异。在pSS中，sVCAM-1与VAS呈正相关（rS = 0.52，p = 0.04）和福克斯试验呈正相关（rS = 0.66，p = 0.01）。在sSS中，sE-选择素与sICAM-1呈正相关（rS = 0.54，p = 0.01）、与疾病持续时间呈正相关（rS = 0.51，p = 0.03），与施默试验呈负相关（rS = 0.59，p = 0.04）。sICAM-1与红细胞沉降率（ESR）值呈正相关（rS = 0.59，p = 0.01）。