Ghahremanloo Atefe, Hajipour Reza, Hemmati Mina, Moossavi Maryam, Mohaqiq Zabihullah
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Birjand CardioVascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
J Complement Integr Med. 2017 Oct 24;15(2):/j/jcim.2018.15.issue-2/jcim-2017-0051/jcim-2017-0051.xml. doi: 10.1515/jcim-2017-0051.
Background Prevention and treatment of obesity is a way to reduce cardiovascular disease, diabetes and depression. Pumpkin as a favorable plant has different properties notably antioxidant, lipid-lowering and anti-diabetic potential. The aim of this study was to assess the anti-obesity effects of pumpkin in diet-induced obese rats. Methods Thirty adult male Wistar rats were randomly divided into five groups (n=6) of healthy control, dietary fatty control rats, and three experimental dietary fatty rats that received hydro-alcoholic extract of pumpkin once daily at doses 100 and 200 and 400 mg/kg, respectively. At the end of 6 weeks, lipid profile, atherogenicity, liver enzymes, and oxidative stress status were measured. Results Pumpkin in a dose-dependent manner dramatically decreased triglycerides and low-density lipoprotein, and liver enzymes while high-density lipoprotein was markedly increased in treated groups. Pumpkin also increased glutathione level in comparison with obese control group. Conclusions Pumpkin ameliorated oxidative stress and dyslipidemia in obese rats, leading to decrease cardiovascular disease risk in obesity.
背景 肥胖的预防和治疗是降低心血管疾病、糖尿病和抑郁症的一种方法。南瓜作为一种有益的植物具有不同的特性，尤其是抗氧化、降血脂和抗糖尿病的潜力。本研究的目的是评估南瓜对饮食诱导肥胖大鼠的抗肥胖作用。方法 将30只成年雄性Wistar大鼠随机分为五组（n = 6）：健康对照组、饮食脂肪对照组大鼠，以及三组实验性饮食脂肪大鼠，分别每天以100、200和400 mg/kg的剂量给予南瓜水醇提取物。在6周结束时，测量血脂、动脉粥样硬化性、肝酶和氧化应激状态。结果 南瓜以剂量依赖性方式显著降低甘油三酯和低密度脂蛋白以及肝酶，而治疗组中的高密度脂蛋白显著增加。与肥胖对照组相比，南瓜还提高了谷胱甘肽水平。结论 南瓜改善了肥胖大鼠的氧化应激和血脂异常，从而降低了肥胖症中心血管疾病的风险。
