Vidal Adriana C, Chen Zinan, Howard Lauren E, Moreira Daniel M, Castro-Santamaria Ramiro, Andriole Gerald L, Taioli Emanuela, Fowke Jay H, Knudsen Beatrice, Drake Charles G, Nickel J Curtis, Freedland Stephen J
Department of Surgery, Division of Urology, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
Oncotarget. 2016 Jul 18;8(42):71393-71399. doi: 10.18632/oncotarget.10690. eCollection 2017 Sep 22.
Prostate cancer (PC) risk differs between races, and we previously showed prostate inflammation in benign prostate tissue was linked with a lower future PC risk. However, whether prostate tissue inflammation varies by race is unknown. We analyzed baseline acute and chronic prostate inflammation by race in REDUCE, a 4-year, multicenter, placebo-controlled study where all men had a negative prostate biopsy prior to enrollment. We included 7,982 men with standardized central pathology review to determine the presence or absence of chronic or acute inflammation in baseline prostate biopsy tissue. Logistic regression was used to compare prostate inflammation by race, adjusting for confounders. Of 7,982 men, 7,271 were white (91.1%), 180 (2.3%) black, 131 (1.6%) Asian, 319 (4.0%) Hispanic and 81 (1%) unknown. A total of 78% had chronic and 15% had acute inflammation. On multivariable analysis relative to white men, black men were less likely (OR = 0.65, 95%CI: 0.41-1.03, = 0.07) and Asian men more likely to have acute inflammation (OR = 1.74, 95%CI: 1.14-2.65, = 0.001). Hispanic men had similar levels of acute inflammation as white men. Chronic inflammation did not significantly differ across races. We identified racial differences in acute inflammation, particularly in Asian men, in benign prostate tissue that inversely mirrored population-level data on PC race disparity. As we showed in REDUCE that acute inflammation is linked with lower future PC risk, if validated in future studies, these data suggest racial differences in prostatic acute inflammation may contribute in part to race differences in PC risk, especially among Asian men.
前列腺癌（PC）风险在不同种族之间存在差异，我们之前的研究表明，良性前列腺组织中的前列腺炎症与未来较低的PC风险相关。然而，前列腺组织炎症是否因种族而异尚不清楚。我们在REDUCE研究中按种族分析了基线时的急性和慢性前列腺炎症，这是一项为期4年的多中心、安慰剂对照研究，所有男性在入组前前列腺活检结果均为阴性。我们纳入了7982名男性，通过标准化的中心病理检查来确定基线前列腺活检组织中是否存在慢性或急性炎症。采用逻辑回归按种族比较前列腺炎症情况，并对混杂因素进行了调整。在7982名男性中，7271名是白人（91.1%），180名是黑人（2.3%），131名是亚洲人（1.6%），319名是西班牙裔（4.0%），81名（1%）种族不明。共有78%的人有慢性炎症，15%的人有急性炎症。多变量分析显示，与白人男性相比，黑人男性发生急性炎症的可能性较小（比值比[OR]=0.65，95%置信区间[CI]：0.41-1.03，P=0.07），而亚洲男性发生急性炎症的可能性较大（OR=1.74，95%CI：1.14-2.65，P=0.001）。西班牙裔男性的急性炎症水平与白人男性相似。慢性炎症在不同种族之间没有显著差异。我们发现良性前列腺组织中急性炎症存在种族差异，尤其是在亚洲男性中，这与PC种族差异的人群水平数据呈相反关系。正如我们在REDUCE研究中所表明的，急性炎症与未来较低的PC风险相关，如果在未来研究中得到验证，这些数据表明前列腺急性炎症的种族差异可能部分导致了PC风险的种族差异，尤其是在亚洲男性中。
